Kedilerde Kronik Böbrek Hastalığında FGF-23’ün Klinik Kullanımı

Deniz Zeynep Telci; Banu Dokuzeylül; M. Erman Or

doi:10.51755/turkvetj.1835180

EN TR

Clinical Use of FGF-23 in Feline Chronic Kidney Disease

Öz

Fibroblast growth factor-23 (FGF-23) is a hormone synthesized primarily by osteocytes and other bone cells, playing a key role in the regulation of phosphate metabolism. Its main effects include increasing renal phosphate excretion to reduce serum phosphate levels and limiting intestinal phosphate absorption by suppressing 1α-hydroxylase activity and consequently decreasing calcitriol synthesis. In cats with chronic kidney disease (CKD), plasma FGF-23 concentrations have been observed to increase in parallel with the loss of renal function and advancing IRIS stage. When cats with chronic kidney disease are compared, the detection of higher FGF-23 levels in hyperphosphatemic individuals suggests that this hormone may serve as an early biomarker reflecting disturbances in phosphate metabolism. Studies indicate that FGF-23 may be useful not only in the diagnosis of CKD but also in the diagnosis of secondary renal hyperparathyroidism and in monitoring phosphate-restricted therapeutic interventions. This review aims to provide a comprehensive evaluation of the association of FGF-23 with CKD in cats, its pathophysiological role, and its potential applications in veterinary clinical practice.

Anahtar Kelimeler

Kedilerde Kronik Böbrek Hastalığında FGF-23’ün Klinik Kullanımı

Öz

Fibroblast büyüme faktörü-23 (FGF-23), başlıca osteositler olmak üzere kemik hücrelerinden sentezlenen ve fosfat metabolizmasının düzenlenmesinde kilit rol oynayan bir hormondur. Temel etkileri, böbreklerden fosfat atılımını artırarak serum fosfat düzeylerini düşürmek ve 1α-hidroksilaz aktivitesini baskılayarak kalsitriol sentezini azaltmak yoluyla bağırsaktan fosfat emilimini sınırlamaktır. Kronik böbrek hastalığı (KBH) bulunan kedilerde plazma FGF-23 düzeyinin, böbrek fonksiyon kaybı ve IRIS evresinin ilerlemesi ile birlikte yükseldiği gözlemlenmiştir. Kronik böbrek hastalığı bulunan kediler karşılaştırıldığında, hiperfosfatemili olgularda daha yüksek FGF-23 düzeylerinin saptanması, bu hormonun fosfat metabolizmasındaki bozulmayı erken dönemde yansıtan bir biyobelirteç olabileceğini düşündürmektedir. Yapılan araştırmalar FGF-23’ün yalnızca KBH tanısında değil, sekonder renal hiperparatiroidizmin tanısında ve fosfat kısıtlamasına dayalı tedavilerin izlenmesinde de yararlı bir biyobelirteç olabileceğini göstermektedir. Bu derlemede, FGF-23’ün kedilerde KBH ile ilişkisinin, patofizyolojik rolünün ve veteriner pratiğinde kullanım olanaklarının kapsamlı şekilde değerlendirilmesi amaçlanmıştır.

Anahtar Kelimeler

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Veteriner Bilimleri (Diğer)

Bölüm

Derleme

Yazarlar

Deniz Zeynep Telci ^*
0000-0001-6825-2093
Türkiye

Banu Dokuzeylül
0000-0003-3086-4726
Türkiye

M. Erman Or
0000-0002-8764-1956
Türkiye

Yayımlanma Tarihi

30 Haziran 2026

Gönderilme Tarihi

3 Aralık 2025

Kabul Tarihi

13 Mayıs 2026

Yayımlandığı Sayı

Yıl 2026 Cilt: 8 Sayı: 1

DOI

https://doi.org/10.51755/turkvetj.1835180

IZ

https://izlik.org/JA92WC83BE

Kaynak Göster

RIS / Bibtex

APA

Telci, D. Z., Dokuzeylül, B., & Or, M. E. (2026). Kedilerde Kronik Böbrek Hastalığında FGF-23’ün Klinik Kullanımı. Turkish Veterinary Journal, 8(1), 20-25. https://doi.org/10.51755/turkvetj.1835180

AMA

1.Telci DZ, Dokuzeylül B, Or ME. Kedilerde Kronik Böbrek Hastalığında FGF-23’ün Klinik Kullanımı. Turk Vet J. 2026;8(1):20-25. doi:10.51755/turkvetj.1835180

Chicago

Telci, Deniz Zeynep, Banu Dokuzeylül, ve M. Erman Or. 2026. “Kedilerde Kronik Böbrek Hastalığında FGF-23’ün Klinik Kullanımı”. Turkish Veterinary Journal 8 (1): 20-25. https://doi.org/10.51755/turkvetj.1835180.

EndNote

Telci DZ, Dokuzeylül B, Or ME (01 Haziran 2026) Kedilerde Kronik Böbrek Hastalığında FGF-23’ün Klinik Kullanımı. Turkish Veterinary Journal 8 1 20–25.

IEEE

[1]D. Z. Telci, B. Dokuzeylül, ve M. E. Or, “Kedilerde Kronik Böbrek Hastalığında FGF-23’ün Klinik Kullanımı”, Turk Vet J, c. 8, sy 1, ss. 20–25, Haz. 2026, doi: 10.51755/turkvetj.1835180.

ISNAD

Telci, Deniz Zeynep - Dokuzeylül, Banu - Or, M. Erman. “Kedilerde Kronik Böbrek Hastalığında FGF-23’ün Klinik Kullanımı”. Turkish Veterinary Journal 8/1 (01 Haziran 2026): 20-25. https://doi.org/10.51755/turkvetj.1835180.

JAMA

1.Telci DZ, Dokuzeylül B, Or ME. Kedilerde Kronik Böbrek Hastalığında FGF-23’ün Klinik Kullanımı. Turk Vet J. 2026;8:20–25.

MLA

Telci, Deniz Zeynep, vd. “Kedilerde Kronik Böbrek Hastalığında FGF-23’ün Klinik Kullanımı”. Turkish Veterinary Journal, c. 8, sy 1, Haziran 2026, ss. 20-25, doi:10.51755/turkvetj.1835180.

Vancouver

1.Deniz Zeynep Telci, Banu Dokuzeylül, M. Erman Or. Kedilerde Kronik Böbrek Hastalığında FGF-23’ün Klinik Kullanımı. Turk Vet J. 01 Haziran 2026;8(1):20-5. doi:10.51755/turkvetj.1835180