Bağırsakta bağırır: Atopik dermatitli köpeklerde ‘bağırsak-beyin-deri ekseninde’ fekal intestinal alkalen fosfataz aktivitesinin ve çinko seviyelerinin ölçümü

Kerem Ural; Serdar Paşa; Hasan Erdoğan; Songül Erdoğan; Tahir Özalp

doi:10.51755/turkvetj.1780858

TR EN

Bağırsakta bağırır: Atopik dermatitli köpeklerde ‘bağırsak-beyin-deri ekseninde’ fekal intestinal alkalen fosfataz aktivitesinin ve çinko seviyelerinin ölçümü

Öz

Gastrointestinal fizyolojide ve hastalıklarda kritik rolde olan izoenzim grubuna ait biyobelirtec olan fekal intestinal alkalen fosfataz’ın (F-IAP), beyin-bağırsak-deri ekseninde tanısal manada etkin olup olmadığının belirlenmesi hipotezinden yola çıkılarak gerçekleştirilen bu çalışma çift-kör, randomize, prospektif olarak planlanmıştır. Bu çalışmada bağırsak-beyin-deri ekseni odaklı değerlendirmede, aynı çalışma ekibinin önceki birikimleri, deneyimler ve çalışmaları bir adım öteye taşınarak atopik dermatitli köpeklerde alanımızda ilk olarak F-IAP aktivitesindeki değişimin, i) yeni bir gastroentero-dermatolojik sağlık biyobelirteci potansiyelini taşıyıp taşımayacağının belirlenmesi, ii) çinko seviyeleri ile olan ilişkisinin değerlendirilmesi, iii) intestinal mukoza koruyucu etkisinin bu hastalık aktivitesine ilişkin olarak azalıp azalmadığının belirlenmesi amaçlanmıştır. Çalışma kapsamına alınan n=14 atopik dermatitli ve karşılaştırmalı n=12 sağlıklı köpekte F-IAP ve serum çinko seviyeleri ölçüldü. Atopik dermatitli köpeklerde ortalama F-IAP değeri 13,8 IU/L iken sağlıklı kontrol grubunda 56,8 IU/L olarak ölçüldü (P = 0,0001). Benzer şekilde, serum çinko düzeyleri de atopik dermatitli bireylerde anlamlı derecede azalmış olup, bu grupta ortalama çinko düzeyi 0,696 mg/L, sağlıklı grupta ise 7,588 mg/L olarak belirlendi (P = 0,0001). Elde edilen sonuçlara bakıldığında atopik dermatitli köpeklerde gerek F-IAP gerekse Zn aktivitelerinde değişim meydana geldiğini öne sürmek yerinde olacaktır. Bulgular, sağaltım protokollerinde değişimi zorlayacaktır.

Anahtar Kelimeler

The Gut Speaks Loudly: Measurement of Fecal Intestinal Alkaline Phosphatase Activity and Zinc Levels Along the Gut–Brain–Skin Axis in Dogs with Atopic Dermatitis

Abstract

This double-blind, randomized, prospective study was conducted based on the hypothesis of whether a biomarker belonging isoenzyme group as fecal intestinal alkaline phosphatase, which plays a critical role in gastrointestinal physiology and diseases, is diagnostically effective within the brain-gut-skin axis. In this study, focusing on the gut-brain-skin axis, the previous findings, experiences, and studies of the same research team were advanced one step further. The aims were: i) to determine whether the change in F-IAP activity in dogs with atopic dermatitis has the potential to serve as a novel gastroentero-dermatological health biomarker, ii) to evaluate its relationship with zinc levels, and iii) to assess whether its intestinal mucosa-protective effect is reduced in relation to the activity of this disease. In this study, F-IAP and serum zinc levels were measured in n=14 dogs with atopic dermatitis and n=12 healthy control dogs. The mean F-IAP level in dogs with atopic dermatitis was 13.8 IU/L, while it was 56.8 IU/L in the healthy control group (P = 0.0001). Similarly, serum zinc levels were significantly decreased in individuals with atopic dermatitis; the mean zinc level in this group was 0.696 mg/L, compared to 7.588 mg/L in the healthy group (P = 0.0001). Based on the findings, it would be appropriate to suggest that both F-IAP and Zn activities are altered in dogs with atopic dermatitis. These results may compel modifications in therapeutic protocols.

Keywords

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Veteriner Bilimleri (Diğer)

Bölüm

Araştırma Makalesi

Yazarlar

Kerem Ural
0000-0003-1867-7143
Türkiye

Serdar Paşa
0000-0003-4957-9263
Türkiye

Hasan Erdoğan
0000-0001-5141-5108
Türkiye

Songül Erdoğan
0000-0002-7833-5519
Türkiye

Tahir Özalp ^*
0000-0002-9873-0364
Türkiye

Yayımlanma Tarihi

29 Aralık 2025

Gönderilme Tarihi

9 Eylül 2025

Kabul Tarihi

15 Ekim 2025

Yayımlandığı Sayı

Yıl 2025 Cilt: 7 Sayı: 2

DOI

https://doi.org/10.51755/turkvetj.1780858

IZ

https://izlik.org/JA43CN32ZW

Kaynak Göster

RIS / Bibtex

APA

Ural, K., Paşa, S., Erdoğan, H., Erdoğan, S., & Özalp, T. (2025). Bağırsakta bağırır: Atopik dermatitli köpeklerde ‘bağırsak-beyin-deri ekseninde’ fekal intestinal alkalen fosfataz aktivitesinin ve çinko seviyelerinin ölçümü. Turkish Veterinary Journal, 7(2), 43-47. https://doi.org/10.51755/turkvetj.1780858