Investigation of the Effectiveness of Turkish Propolis on Experimentally Induced Intraperitoneal Adhesions in Rats

Nuh Kılıç; Ali Belge; Rahime Yaygıngül; Büşra Kibar; Selim Tekin

doi:10.51755/turkvetj.1926231

EN TR

Investigation of the Effectiveness of Turkish Propolis on Experimentally Induced Intraperitoneal Adhesions in Rats

Abstract

Postoperatif intraperitoneal adezyonlar hem insan hem de veteriner cerrahisinde önemli bir morbidite nedeni olmaya devam etmektedir. Bu çalışmada, deneysel olarak oluşturulan intraperitoneal adezyonlar üzerine Türk propolisinin etkilerinin değerlendirilmesi amaçlandı. Çalışmada elli adet erkek Sprague–Dawley rat rastgele beş gruba ayrıldı (n=10). Adezyonlar, ketamin–ksilazin anestezisi altında median laparotomi sonrası terminal ileum ve çekumda standartlaştırılmış serozal abrazyon ve iskemi oluşturularak meydana getirildi. Tedavi gruplarına topikal propolis, oral propolis (14 gün boyunca 4 g/kg/gün) veya her iki uygulamanın kombinasyonu verildi. Adezyonlar postoperatif 14. günde Nair adezyon skorlama sistemine göre makroskopik olarak değerlendirildi. Adezyon skorlarının kontrol grubunda en yüksek (11.5 ± 6.1), oral propolis grubunda ise en düşük (1.5 ± 1.2) olduğu belirlendi. Hem topikal hem de oral propolis uygulamalarının kontrol grubuna kıyasla adezyon şiddetini azalttığı, en belirgin koruyucu etkinin ise oral propolis grubunda gözlendiği tespit edildi. Bu bulgular, Türk propolisinin postoperatif intraperitoneal adezyon oluşumunun önlenmesinde umut verici doğal bir terapötik ajan olabileceğini düşündürmektedir.

Keywords

Ratlarda Deneysel Olarak Oluşturulan İntraperitoneal adhezyon üzerine Türk Propolisin Etkinliğinin Araştırılması

Abstract

Postoperatif intraperitoneal adezyonlar hem insan hem de veteriner cerrahisinde önemli bir morbidite nedeni olmaya devam etmektedir. Bu çalışmada, deneysel olarak oluşturulan intraperitoneal adezyonlar üzerine Türk propolisinin etkilerinin değerlendirilmesi amaçlandı. Çalışmada elli adet erkek Sprague–Dawley rat rastgele beş gruba ayrıldı (n=10). Adezyonlar, ketamin–ksilazin anestezisi altında median laparotomi sonrası terminal ileum ve çekumda standartlaştırılmış serozal abrazyon ve iskemi oluşturularak meydana getirildi. Tedavi gruplarına topikal propolis, oral propolis (14 gün boyunca 4 g/kg/gün) veya her iki uygulamanın kombinasyonu verildi. Adezyonlar postoperatif 14. günde Nair adezyon skorlama sistemine göre makroskopik olarak değerlendirildi. Adezyon skorlarının kontrol grubunda en yüksek (11.5 ± 6.1), oral propolis grubunda ise en düşük (1.5 ± 1.2) olduğu belirlendi. Hem topikal hem de oral propolis uygulamalarının kontrol grubuna kıyasla adezyon şiddetini azalttığı, en belirgin koruyucu etkinin ise oral propolis grubunda gözlendiği tespit edildi. Bu bulgular, Türk propolisinin postoperatif intraperitoneal adezyon oluşumunun önlenmesinde umut verici doğal bir terapötik ajan olabileceğini düşündürmektedir.

Keywords

Supporting Institution

This research was supported by Aydın Adnan Menderes University Scientific Research Projects Unit with project number VTF-18031

Ethical Statement

All experimental procedures were approved by the Local Animal Ethics Committee of Aydın Adnan Menderes University (Approval No: 64583101/2018/020).

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Details

Primary Language

English

Subjects

Veterinary Surgery

Journal Section

Research Article

Authors

Nuh Kılıç ^*
0000-0001-8452-161X
Türkiye

Ali Belge
0000-0003-3346-6926
Türkiye

Rahime Yaygıngül
0000-0001-7402-9031
Türkiye

Büşra Kibar
0000-0002-1490-8832
Türkiye

Selim Tekin
0009-0004-9785-9897
Türkiye

Publication Date

June 30, 2026

Submission Date

April 10, 2026

Acceptance Date

June 17, 2026

Published in Issue

Year 2026 Volume: 8 Number: 1

DOI

https://doi.org/10.51755/turkvetj.1926231

IZ

https://izlik.org/JA99YB33TD

Cite

RIS / Bibtex

APA

Kılıç, N., Belge, A., Yaygıngül, R., Kibar, B., & Tekin, S. (2026). Investigation of the Effectiveness of Turkish Propolis on Experimentally Induced Intraperitoneal Adhesions in Rats. Turkish Veterinary Journal, 8(1), 14-19. https://doi.org/10.51755/turkvetj.1926231

AMA

1.Kılıç N, Belge A, Yaygıngül R, Kibar B, Tekin S. Investigation of the Effectiveness of Turkish Propolis on Experimentally Induced Intraperitoneal Adhesions in Rats. Turk Vet J. 2026;8(1):14-19. doi:10.51755/turkvetj.1926231

Chicago

Kılıç, Nuh, Ali Belge, Rahime Yaygıngül, Büşra Kibar, and Selim Tekin. 2026. “Investigation of the Effectiveness of Turkish Propolis on Experimentally Induced Intraperitoneal Adhesions in Rats”. Turkish Veterinary Journal 8 (1): 14-19. https://doi.org/10.51755/turkvetj.1926231.

EndNote

Kılıç N, Belge A, Yaygıngül R, Kibar B, Tekin S (June 1, 2026) Investigation of the Effectiveness of Turkish Propolis on Experimentally Induced Intraperitoneal Adhesions in Rats. Turkish Veterinary Journal 8 1 14–19.

IEEE

[1]N. Kılıç, A. Belge, R. Yaygıngül, B. Kibar, and S. Tekin, “Investigation of the Effectiveness of Turkish Propolis on Experimentally Induced Intraperitoneal Adhesions in Rats”, Turk Vet J, vol. 8, no. 1, pp. 14–19, June 2026, doi: 10.51755/turkvetj.1926231.

ISNAD

Kılıç, Nuh - Belge, Ali - Yaygıngül, Rahime - Kibar, Büşra - Tekin, Selim. “Investigation of the Effectiveness of Turkish Propolis on Experimentally Induced Intraperitoneal Adhesions in Rats”. Turkish Veterinary Journal 8/1 (June 1, 2026): 14-19. https://doi.org/10.51755/turkvetj.1926231.

JAMA

1.Kılıç N, Belge A, Yaygıngül R, Kibar B, Tekin S. Investigation of the Effectiveness of Turkish Propolis on Experimentally Induced Intraperitoneal Adhesions in Rats. Turk Vet J. 2026;8:14–19.

MLA

Kılıç, Nuh, et al. “Investigation of the Effectiveness of Turkish Propolis on Experimentally Induced Intraperitoneal Adhesions in Rats”. Turkish Veterinary Journal, vol. 8, no. 1, June 2026, pp. 14-19, doi:10.51755/turkvetj.1926231.

Vancouver

1.Nuh Kılıç, Ali Belge, Rahime Yaygıngül, Büşra Kibar, Selim Tekin. Investigation of the Effectiveness of Turkish Propolis on Experimentally Induced Intraperitoneal Adhesions in Rats. Turk Vet J. 2026 Jun. 1;8(1):14-9. doi:10.51755/turkvetj.1926231