Ana Hatları ile Ferroptozis

Arzu Gezer; Ebru Karadağ Sarı

doi:10.51755/turkvetj.1078397

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Ana Hatları ile Ferroptozis

Öz

Ferroptozis, son yıllarda keşfedilen ve hücre ölümü sürecinde büyük miktarda demir birikimi ve lipid peroksidasyonunun görüldüğü, GPX4 tarafından kontrol edilen hücre ölümü biçimidir. Glutatyon peroksidaz doğrudan veya dolaylı olarak ferroptozisi etkileyerek antioksidan kapasitede azalmaya ve hücrelerde lipid reaktif oksijen türlerinin (ROS) birikmesine neden olarak oksidatif hücre ölümüne sebep olur. Çoklu doymamış yağ asidi içeren fosfolipidlerin oksidasyonu, redoks-aktif demir birikimi ve lipid peroksit onarım kapasitesinin kaybı ferroptozisin meydana gelme derecesinde kriter olarak kullanılır. Son zamanlarda yapılan çalışmalarla ferroptozisin; tümör, sinir sistemi ve kan hastalıkları, böbrek hasarı, iskemi-reperfüzyon hasarı gibi birçok hastalığın patofizyolojik süreçleri ile ilişkili olduğu gösterilmiştir. Hücrede ferroptozisin düzenlenerek hastalıkların oluşumuna ve gelişimine nasıl müdahale edilebileceği, etiyolojik araştırma ve tedavinin önemli noktası haline gelmiştir. Bundan dolayı ferroptozisin spesifik moleküler mekanizmalarının ve fonksiyonel değişikliklerinin açıklandığı daha fazla araştırmaya ihtiyaç vardır. Bu çalışma ferroptozis mekanizması ve patogenezinin anlaşılmasını amaçlayarak, araştırmalardaki son ilerlemeleri özetlemektedir.

Anahtar Kelimeler

Ferroptosis with Outlines

Abstract

Ferroptosis is a form of cell death controlled by GPX4, discovered in recent years, in which a large accumulation of iron and lipid peroxidation is observed in the process of cell death. Glutathione peroxidase directly or indirectly affects ferroptosis, causing a decrease in antioxidant capacity and the accumulation of lipid reactive oxygen species (ROS) in cells, resulting in oxidative cell death. Oxidation of phospholipids containing polyunsaturated fatty acids, accumulation of redox-active iron and loss of lipid peroxide repair capacity are used as criteria for the degree of occurrence of ferroptosis. Recent studies have shown that ferroptosis is associated with the pathophysiological processes of many diseases, such as tumors, diseases of the nervous system and blood, kidney damage, ischemia-reperfusion injury. How ferroptosis can be regulated in the cell and interfere with the formation and development of diseases has become an important point of etiological research and treatment. Therefore, further research is needed in which the specific molecular mechanisms and functional changes of ferroptosis are explained. This study aims to understand the mechanism and pathogenesis of ferroptosis and summarizes the recent advances in research.

Keywords

References

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Details

Primary Language

Turkish

Subjects

Veterinary Surgery

Journal Section

Review

Authors

Arzu Gezer ^*
0000-0002-1658-2098
Türkiye

Ebru Karadağ Sarı
0000-0001-7581-6109
Türkiye

Publication Date

December 23, 2022

Submission Date

February 24, 2022

Acceptance Date

June 16, 2022

Published in Issue

Year 2022 Volume: 4 Number: 1

DOI

https://doi.org/10.51755/turkvetj.1078397

IZ

https://izlik.org/JA74CB62YZ

Cite

RIS / Bibtex

APA

Gezer, A., & Karadağ Sarı, E. (2022). Ana Hatları ile Ferroptozis. Turkish Veterinary Journal, 4(1), 24-27. https://doi.org/10.51755/turkvetj.1078397