Köpeklerde Proflaktik Gastropeksi Tekniklerin Gastrin Hormonu ve Pankreas Enzim Seviyelerine Etkisinin Araştırılması
Abstract
Gastrik dilatasyon volvulus problemine predispoze ırk olan 15 köpeğe proflaktik amaçla endoskopik gastropeksi, laparoskopik gastropeksi ve ventral orta hat gastropeksi tekniklerini uygulayarak, iyileşme sürecinde mideden ve pankreastan salgılanan amilaz, lipaz ve gastrin seviyelerindeki değişiklikleri karşılaştırılarak tekniklerin avantaj ve dezavantajları araştırıldı.
Çalışmada 15 köpek, orta ventral hat, laparoskopik ve endoskopik destekli gastropeksi için 3 gruba ayrıldı. Birinci gruptaki 5 köpekte klasik gastropeksi, İkinci gruptaki köpeklerde laparoskopik destekli gastropeksi ve üçüncü gruptaki köpeklerde ise endoskopik gastropeksi operasyonu uygulandı. Her gruptaki köpeğe preoperative, postoperative 1. gün ve 8. günde amilaz, lipaz ve gastrin ölçümleri yapılarak elde edilen veriler istatistiksel olarak değerlendirildi. Operasyon sonunda klinik olarak herhangi bir patolojiye rastlanılmadı. Elde edilen amilaz, lipaz ve gastrin seviyeleride normal standart referanslar aralığında bulundu.
Sonuç olarak, enzim salınımları yönünden yapılan operasyon tekniklerinin birbirlerine istatistik açıdan bir üstünlükleri olmadığını destekler niteliktedir. Tekniklerin uygulama ve zaman olarak birbirlerine avantaj ve dezavantajları bulunsa dahi bu üç teknikten herhangi bir tanesinin amilaz, lipaz ve gastrin enzimlerinin enzimatik sonuçları yönünden istatistiki bir fark oluşturmayacağı, her üç tekniğin de profilaktik amaçla kullanılabileceği görüşü ağırlık kazanmıştır. Fakat post-operatif dönemin daha uzun tutulması ile enzimatik ve mide motilitesinde değişikliklerin olabileceği düşünülmektedir. Bu açıdan daha fazla olgu ile daha uzun post-operatif dönem değerlendirilmelidir.
Keywords
Supporting Institution
Selçuk Üniversitesi, BAP Koordinatörlüğü
Project Number
18202059
Thanks
Osman İncekara’nın Yüksek Lisans tez projesi S.Ü.BAP Koordinatörlüğünün 18202059 proje no ile desteklenmiştir. Ayrıca Bremen's Veteriner Sağlık Hizmetleri Kliniği çalışanlarına destek ve katkılarından dolayı teşekkür ederiz.
References
- Reference1-Allen P, Paul A (2014) Gastropexy for prevention of gastric dilatation-volvulus in dogs: history and techniques. Top Companion Anim Med 29:77-80. https://doi.org/10.1053/j.tcam.2014.09.001
- Reference2-Arıcan M, Parlak K, Erol H, Yavru N (2014a) Köpeklerde laparoskopik destekli gastropeksi ile klasik gastropeksi operasyonunun karşılaştırılması. Eurasian J Vet Sci 30:195-202. https://doi.org/10.15312/EurasianJVetSci.201447376
- Reference3-Arıcan M, Parlak K, İnce ME, Güzelbektaş H (2014b) Result of endoscopically assisted gastropexy in dogs. Acta Vet-Beograd 64:226-235. https://doi.org/10.2478/acve-2014-0021
- Reference4-Balsa IM, Culp W, Drobatz KJ, Johnson EG, Mayhew PD, & Marks SL (2017) Effect of Laparoscopic-assisted Gastropexy on Gastrointestinal Transit Time in Dogs. J Vet Intern Med 31:1680–1685. https://doi.org/10.1111/jvim.14816
- Reference5-Beck J, Staatz A, Pelsue H (2006). Risc factors associated with short term outcome and development of perioperative complications in dogs undergoing surgery because of GDV 166 Cases 1992-2003. J Am Vet Med Assoc 229:1934-1939.
- Reference6-Çalım KN, Arıcan M (2008) Farklı Gastropeksi Yöntemleri Uygulanan Köpeklerde gastrik boşalma oranlarının sindirilmeyen radyopak maddelerle değerlendirilmesi. Vet Bil Derg 2:27-39.
- Reference7-Dujowich M, Keller ME, Reimer SB (2010). Evaluation of short- and long-term complications after endoscopically assisted gastropexy in dogs. J Am Vet Med Assoc 236:177-182. https://doi.org/10.2460/javma.236.2.177.
- Reference8-Fossum T (2013) Surgery of the abdominal cavity.In: Fossum TW Dewey CW, Horn CV, Johnson AL, Radlinsky MG, Shulz KS, Willard MD (eds) Small Animal Surgery, 4th edn. Elsevier, Missouri, pp. 356-516.
- Reference9-Glickman LT, Glickman NW, Pérez CM (1994) Analysis of risk factors for gastric dilatation and dilatation-volvulus in dogs. J Am Vet Med Assoc 204:1465-1471.
- Reference10-Hall JA, Willer RL, Solie TN, Twedt DC (2008) Effect on circumcostal gastropexy on gastric myoelectric and motor activity in dogs. J Small Animal Pract 38:200-207. https://doi.org/10.1111/j.1748-5827.1997.tb03342.x
- Reference11-Haraguchi T, Kimura S, Itoh H, Nishikawa S, Hiyama M, Tani K, Iseri T, Itoh Y, Nakaichi M, Taura Y, Itamoto K (2017) Comparison of postoperative pain and inflammation reaction in dogs undergoing preventive laparoscopic-assisted and incisional gastropexy. J Vet Med Sci 79:1524-1531. https://doi.org/10.1292/jvms.17-0103
- Reference12-Meyer-Lindenberg A (1998). Ventral midline gastropexy. In: Bojrab MJ (ed) Current Techniques in Small Animal Surgery, 4th edn, Lea & Febiger, Philadelphia, pp. 241-243.
- Reference13-Rawlings CA, Foutz TL, Mahaffey MB, Howerth EW, Bement S, Canalis C (2001). A rapid and strong laparoscopic-assisted gastropexy in dogs, Am J Vet Res 62: 871-875. https://doi.org/10.2460/ajvr.2001.62.871
- Reference14-Tavakoli A, Mahmoodifard M, Razavifard AH (2016) The superiority of paracostal endoscopic-assisted gastropexy over open incisional and belt loop gastropexy in dogs: a comparison of three prophylactic techniques. Iran J Vet Res 17:118,123. https://doi.org/10.22099/IJVR.2016.3736
- Reference15-Turgut K (2000) Veteriner Klinik Laboratuar Teşhis. Birinci baskı, Konya ss. 259-319.
- Reference16-Ward MP, Patronek GJ, Glickman LT (2003) Benefits of prophylactic gastropexy for dogs at risk of gastric dilatation-volvulus. Prev Vet Med 60:319-329. https://doi.org/10.1016/s0167-5877(03)00142-9
- Reference17-Watson S, Durrant L, Morris D (1989) Gastrin: growth enhancing effects on human gastric and colonic tumour cells. Br J Cancer 59:554-558. https://doi.org/10.1038/bjc.1989.112
- Reference18-Willard MD, Tvedten H (2004) Gastrointestinal, Pancreatic, and Hepatic Disorders. In: Willard MD, Tvedten H (eds) Small Animall Diagnosis by Laboratory Methods, 4th edn, Saunders, Philadelphia, pp. 208-246.
- Reference19-Xiaoli L, Wu CW, Kim HY, et al. (2017) Gastric acid secretion and gastrin release during continuous vagal neuromonitoring in thyroid surgery. Langenbecks Arch Surg 402:265-272. https://doi.org/10.1007/s00423-017-1555-z
Investigation of the Effect of Prophylactic Gastropexy Techniques on Gastrin Hormone and Pancreatic Enzyme Levels in Dogs
Abstract
The advantages and disadvantages of the techniques were investigated by applying prophylactic endoscopic gastropexy, laparoscopic gastropexy and ventral midline gastropexy techniques to 15 dogs predisposed to gastric dilatation volvulus problem, and comparing the changes in the levels of amylase, lipase and gastrin secreted from the stomach and pancreas during the recovery period.
In the study, 15 dogs were divided into 3 groups for mid-ventral line, laparoscopic and endoscopically assisted gastropexy. Classic gastropexy was performed in 5 dogs in the first group, laparoscopic assisted gastropexy in the dogs in the second group, and endoscopic gastropexy in the dogs in the third group. Preoperative, postoperative 1st day and 8th day amylase, lipase and gastrin measurements were made for the dogs in each group and the data obtained were evaluated statistically. At the end of the operation, no clinical pathology was found. The obtained amylase, lipase and gastrin levels were also within the range of normal standard references.
As a result, it supports the fact that the operation techniques performed in terms of enzyme releases do not have a statistical advantage over each other. Even though the techniques have advantages and disadvantages to each other in terms of application and time, it has been argued that any of these three techniques will not make a statistical difference in terms of the enzymatic results of amylase, lipase and gastrin enzymes, and that all three techniques can be used for prophylactic purposes. However, it is thought that changes in enzymatic and gastric motility may occur with a longer post-operative period. In this respect, a longer post-operative period should be evaluated with more cases.
Keywords
Project Number
18202059
References
- Reference1-Allen P, Paul A (2014) Gastropexy for prevention of gastric dilatation-volvulus in dogs: history and techniques. Top Companion Anim Med 29:77-80. https://doi.org/10.1053/j.tcam.2014.09.001
- Reference2-Arıcan M, Parlak K, Erol H, Yavru N (2014a) Köpeklerde laparoskopik destekli gastropeksi ile klasik gastropeksi operasyonunun karşılaştırılması. Eurasian J Vet Sci 30:195-202. https://doi.org/10.15312/EurasianJVetSci.201447376
- Reference3-Arıcan M, Parlak K, İnce ME, Güzelbektaş H (2014b) Result of endoscopically assisted gastropexy in dogs. Acta Vet-Beograd 64:226-235. https://doi.org/10.2478/acve-2014-0021
- Reference4-Balsa IM, Culp W, Drobatz KJ, Johnson EG, Mayhew PD, & Marks SL (2017) Effect of Laparoscopic-assisted Gastropexy on Gastrointestinal Transit Time in Dogs. J Vet Intern Med 31:1680–1685. https://doi.org/10.1111/jvim.14816
- Reference5-Beck J, Staatz A, Pelsue H (2006). Risc factors associated with short term outcome and development of perioperative complications in dogs undergoing surgery because of GDV 166 Cases 1992-2003. J Am Vet Med Assoc 229:1934-1939.
- Reference6-Çalım KN, Arıcan M (2008) Farklı Gastropeksi Yöntemleri Uygulanan Köpeklerde gastrik boşalma oranlarının sindirilmeyen radyopak maddelerle değerlendirilmesi. Vet Bil Derg 2:27-39.
- Reference7-Dujowich M, Keller ME, Reimer SB (2010). Evaluation of short- and long-term complications after endoscopically assisted gastropexy in dogs. J Am Vet Med Assoc 236:177-182. https://doi.org/10.2460/javma.236.2.177.
- Reference8-Fossum T (2013) Surgery of the abdominal cavity.In: Fossum TW Dewey CW, Horn CV, Johnson AL, Radlinsky MG, Shulz KS, Willard MD (eds) Small Animal Surgery, 4th edn. Elsevier, Missouri, pp. 356-516.
- Reference9-Glickman LT, Glickman NW, Pérez CM (1994) Analysis of risk factors for gastric dilatation and dilatation-volvulus in dogs. J Am Vet Med Assoc 204:1465-1471.
- Reference10-Hall JA, Willer RL, Solie TN, Twedt DC (2008) Effect on circumcostal gastropexy on gastric myoelectric and motor activity in dogs. J Small Animal Pract 38:200-207. https://doi.org/10.1111/j.1748-5827.1997.tb03342.x
- Reference11-Haraguchi T, Kimura S, Itoh H, Nishikawa S, Hiyama M, Tani K, Iseri T, Itoh Y, Nakaichi M, Taura Y, Itamoto K (2017) Comparison of postoperative pain and inflammation reaction in dogs undergoing preventive laparoscopic-assisted and incisional gastropexy. J Vet Med Sci 79:1524-1531. https://doi.org/10.1292/jvms.17-0103
- Reference12-Meyer-Lindenberg A (1998). Ventral midline gastropexy. In: Bojrab MJ (ed) Current Techniques in Small Animal Surgery, 4th edn, Lea & Febiger, Philadelphia, pp. 241-243.
- Reference13-Rawlings CA, Foutz TL, Mahaffey MB, Howerth EW, Bement S, Canalis C (2001). A rapid and strong laparoscopic-assisted gastropexy in dogs, Am J Vet Res 62: 871-875. https://doi.org/10.2460/ajvr.2001.62.871
- Reference14-Tavakoli A, Mahmoodifard M, Razavifard AH (2016) The superiority of paracostal endoscopic-assisted gastropexy over open incisional and belt loop gastropexy in dogs: a comparison of three prophylactic techniques. Iran J Vet Res 17:118,123. https://doi.org/10.22099/IJVR.2016.3736
- Reference15-Turgut K (2000) Veteriner Klinik Laboratuar Teşhis. Birinci baskı, Konya ss. 259-319.
- Reference16-Ward MP, Patronek GJ, Glickman LT (2003) Benefits of prophylactic gastropexy for dogs at risk of gastric dilatation-volvulus. Prev Vet Med 60:319-329. https://doi.org/10.1016/s0167-5877(03)00142-9
- Reference17-Watson S, Durrant L, Morris D (1989) Gastrin: growth enhancing effects on human gastric and colonic tumour cells. Br J Cancer 59:554-558. https://doi.org/10.1038/bjc.1989.112
- Reference18-Willard MD, Tvedten H (2004) Gastrointestinal, Pancreatic, and Hepatic Disorders. In: Willard MD, Tvedten H (eds) Small Animall Diagnosis by Laboratory Methods, 4th edn, Saunders, Philadelphia, pp. 208-246.
- Reference19-Xiaoli L, Wu CW, Kim HY, et al. (2017) Gastric acid secretion and gastrin release during continuous vagal neuromonitoring in thyroid surgery. Langenbecks Arch Surg 402:265-272. https://doi.org/10.1007/s00423-017-1555-z
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Veterinary Surgery |
| Journal Section | Research Article |
| Authors | |
| Project Number | 18202059 |
| Publication Date | December 23, 2022 |
| Published in Issue | Year 2022 |