Koyunlarda tolfenamik asitin farklı dozlarda uygulamasının hematolojik ve biyokimyasal parametrelere etkisi

Orhan Çorum; Duygu Durna Çorum; Ayşe Er; Kamil Üney

doi:10.51755/turkvetj.1398646

EN TR

Effect of different doses of tolfenamic acid on hematological and biochemical parameters in sheep

Abstract

The aim of this study is to determine the change in hematological and biochemical parameters after intravenous administration of tolfenamic acid to sheep at doses of 2, 4, 8 and 16 mg/kg. The research was carried out on 8 healthy Akkaraman breed sheep. Tolfenamic acid was administered intravenously to sheep at doses of 2, 4, 8 and 16 mg/kg. Blood samples were taken before drug administration (0 hour, control) and at 72 hour following the administration. Analysis of hematological parameters was performed on a blood cell counter, and analysis of biochemical parameters was performed on an autoanalyzer. Administration of tolfenamic acid to sheep at doses of 2, 4 and 8 mg/kg did not cause any changes in hematological (white blood cells, red blood cells, hemoglobin, hematocrit and platelets) and biochemical (albumin, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, gamma glutamyl transferase, cholesterol, total bilirubin, triglyceride, creatinine and urea) parameters (p>0.05). While the administration of tolfenamic acid at a dose of 16 mg/kg caused a significant increase in creatinine and urea (p<0.05), no difference was observed in other parameters (p>0.05). As a result, the application of tolfenamic acid to sheep at doses of 2, 4 and 8 mg/kg was well tolerated, while the dose of 16 mg/kg caused undesirable effects on kidney functions. However, there is a need to demonstrate the safety of tolfenamic acid in sheep histopathologically and molecularly.

Keywords

Koyunlarda tolfenamik asitin farklı dozlarda uygulamasının hematolojik ve biyokimyasal parametrelere etkisi

Öz

Bu araştırmanın amacı koyunlara tolfenamik asitin 2, 4, 8 ve 16 mg/kg dozda damar içi yolla uygulaması sonrası hematolojik ve biyokimyasal parametrelerdeki değişimi belirlemektir. Araştırma 8 adet sağlıklı Akkaraman ırkı koyun üzerinde gerçekleştirildi. Koyunlara 2, 4, 8 ve 16 mg/kg dozda tolfenamik asit damar içi yolla uygulandı. Kan örnekleri ilaç uygulaması öncesi (0.saat, kontrol) ve uygulamayı takiben 72. saatte alındı. Hematolojik parametrelerin analizi kan hücresi sayım cihazında ve biyokimyasal parametrelerin analizi otoanalizör cihazında gerçekleştirildi. Koyunlara tolfenamik asitin 2, 4 ve 8 mg/kg dozda uygulaması hematolojik (akyuvar, alyuvar, hemoglobin, hematokrit ve trombosit) ve biyokimyasal parametrelerde (albumin, alkalen fosfataz, alanin aminotransferaz, aspartat aminotransferaz, gama glutamil transferaz, kolesterol, total bilirubin, trigliserit, kreatinin ve üre) herhangi bir değişikliğe neden olmadığı belirlendi (p>0.05). Tolfenamik asitin 16 mg/kg dozda uygulaması kreatinin ve üre değerlerinde önemli artışa neden olurken (p<0.05) diğer parametrelerde herhangi bir farklılık görülmedi (p>0.05). Sonuç olarak tolfenamik asitin koyunlara 2, 4 ve 8 mg/kg dozlarında uygulanması iyi tolere edilirken, 16 mg/kg dozunun böbrek fonksiyonları üzerinde istenmeyen etkilere neden olduğu belirlendi. Ancak koyunlarda tolfenamik asitin güvenilirliğinin histopatolojik ve moleküler olarak ortaya konulmasına ihtiyaç vardır.

Anahtar Kelimeler

Supporting Institution

Türkiye Bilimsel ve Teknolojik Araştırma Kurumu

Project Number

, 215O702

Ethical Statement

Deneysel prosedür için Selçuk Üniversitesi, Veteriner Fakültesi, Etik Kurulu Başkanlığı’ndan Etik onay alındı (2015/44).

Thanks

Bu proje Türkiye Bilimsel ve Teknolojik Araştırma Kurumu (Proje No, 215O702) tarafından finanse edilmiştir.

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Details

Primary Language

Turkish

Subjects

Veterinary Pharmacology

Journal Section

Research Article

Authors

Orhan Çorum ^*
0000-0003-3168-2510
Türkiye

Duygu Durna Çorum
0000-0003-1567-991X
Türkiye

Ayşe Er
0000-0002-6900-0055
Türkiye

Kamil Üney
0000-0002-8674-4873
Türkiye

Early Pub Date

December 27, 2023

Publication Date

December 31, 2023

Submission Date

November 30, 2023

Acceptance Date

December 25, 2023

Published in Issue

Year 2023 Volume: 5 Number: 2

DOI

https://doi.org/10.51755/turkvetj.1398646

IZ

https://izlik.org/JA24KE52TH

Cite

RIS / Bibtex

APA

Çorum, O., Durna Çorum, D., Er, A., & Üney, K. (2023). Koyunlarda tolfenamik asitin farklı dozlarda uygulamasının hematolojik ve biyokimyasal parametrelere etkisi. Turkish Veterinary Journal, 5(2), 44-48. https://doi.org/10.51755/turkvetj.1398646

Cited By

Koyunlarda tolfenamik asitin farklı dozlarda uygulamasının hematolojik ve biyokimyasal parametrelere etkisi

Turkish Veterinary Journal

https://doi.org/10.51755/turkvetj.1398646