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Ana Hatları ile Ferroptozis

Year 2022, Volume: 4 Issue: 1, 24 - 27, 23.12.2022

Arzu Gezer Ebru Karadağ Sarı

https://doi.org/10.51755/turkvetj.1078397

Abstract

Ferroptozis, son yıllarda keşfedilen ve hücre ölümü sürecinde büyük miktarda demir birikimi ve lipid peroksidasyonunun görüldüğü, GPX4 tarafından kontrol edilen hücre ölümü biçimidir. Glutatyon peroksidaz doğrudan veya dolaylı olarak ferroptozisi etkileyerek antioksidan kapasitede azalmaya ve hücrelerde lipid reaktif oksijen türlerinin (ROS) birikmesine neden olarak oksidatif hücre ölümüne sebep olur. Çoklu doymamış yağ asidi içeren fosfolipidlerin oksidasyonu, redoks-aktif demir birikimi ve lipid peroksit onarım kapasitesinin kaybı ferroptozisin meydana gelme derecesinde kriter olarak kullanılır. Son zamanlarda yapılan çalışmalarla ferroptozisin; tümör, sinir sistemi ve kan hastalıkları, böbrek hasarı, iskemi-reperfüzyon hasarı gibi birçok hastalığın patofizyolojik süreçleri ile ilişkili olduğu gösterilmiştir. Hücrede ferroptozisin düzenlenerek hastalıkların oluşumuna ve gelişimine nasıl müdahale edilebileceği, etiyolojik araştırma ve tedavinin önemli noktası haline gelmiştir. Bundan dolayı ferroptozisin spesifik moleküler mekanizmalarının ve fonksiyonel değişikliklerinin açıklandığı daha fazla araştırmaya ihtiyaç vardır. Bu çalışma ferroptozis mekanizması ve patogenezinin anlaşılmasını amaçlayarak, araştırmalardaki son ilerlemeleri özetlemektedir.

Keywords

Demir lipid ferroptozis

References

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Ferroptosis with Outlines

Year 2022, Volume: 4 Issue: 1, 24 - 27, 23.12.2022

Arzu Gezer Ebru Karadağ Sarı

https://doi.org/10.51755/turkvetj.1078397

Abstract

Ferroptosis is a form of cell death controlled by GPX4, discovered in recent years, in which a large accumulation of iron and lipid peroxidation is observed in the process of cell death. Glutathione peroxidase directly or indirectly affects ferroptosis, causing a decrease in antioxidant capacity and the accumulation of lipid reactive oxygen species (ROS) in cells, resulting in oxidative cell death. Oxidation of phospholipids containing polyunsaturated fatty acids, accumulation of redox-active iron and loss of lipid peroxide repair capacity are used as criteria for the degree of occurrence of ferroptosis. Recent studies have shown that ferroptosis is associated with the pathophysiological processes of many diseases, such as tumors, diseases of the nervous system and blood, kidney damage, ischemia-reperfusion injury. How ferroptosis can be regulated in the cell and interfere with the formation and development of diseases has become an important point of etiological research and treatment. Therefore, further research is needed in which the specific molecular mechanisms and functional changes of ferroptosis are explained. This study aims to understand the mechanism and pathogenesis of ferroptosis and summarizes the recent advances in research.

Keywords

Iron lipid ferroptosis

References

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  • Ahmad, S., Elsherbiny, N. M., Haque, R., Khan, M. B., Ishrat, T., Shah, Z. A., ... & Bhatia, K. (2014). Sesamin attenuates neurotoxicity in mouse model of ischemic brain stroke. Neurotoxicology, 45, 100-110.
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  • Chen, M. S., Wang, S. F., Hsu, C. Y., Yin, P. H., Yeh, T. S., Lee, H. C., & Tseng, L. M. (2017). CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2α-ATF4 pathway. Oncotarget, 8(70), 114588.
  • Chu, B., Kon, N., Chen, D., Li, T., Liu, T., Jiang, L., ... & Gu, W. (2019). ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway. Nature cell biology, 21(5), 579-591.
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  • Eling, N., Reuter, L., Hazin, J., Hamacher-Brady, A., & Brady, N. R. (2015). Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells. Oncoscience, 2(5), 517.
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  • Feng, H., & Stockwell, B. R. (2018). Unsolved mysteries: How does lipid peroxidation cause ferroptosis?. PLoS Biology, 16(5), e2006203. Frazer, D. M., & Anderson, G. J. (2014). The regulation of iron transport. Biofactors, 40(2), 206-214.
  • Gammella, E., Recalcati, S., Rybinska, I., Buratti, P., & Cairo, G. (2015). Iron-induced damage in cardiomyopathy: oxidative-dependent and independent mechanisms. Oxidative medicine and cellular longevity, 2015.
  • Gao, M., Monian, P., Quadri, N., Ramasamy, R., & Jiang, X. (2015). Glutaminolysis and transferrin regulate ferroptosis. Molecular cell, 59(2), 298-308.
  • Greenshields, A. L., Shepherd, T. G., & Hoskin, D. W. (2017). Contribution of reactive oxygen species to ovarian cancer cell growth arrest and killing by the anti‐malarial drug artesunate. Molecular carcinogenesis, 56(1), 75-93.
  • Guo, J., Xu, B., Han, Q., Zhou, H., Xia, Y., Gong, C., ... & Wu, G. (2018). Ferroptosis: a novel anti-tumor action for cisplatin. Cancer research and treatment: official journal of Korean Cancer Association, 50(2), 445.
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There are 64 citations in total.

Details

Primary Language Turkish
Subjects Veterinary Surgery
Journal Section Review
Authors

Arzu Gezer 0000-0002-1658-2098

Ebru Karadağ Sarı 0000-0001-7581-6109

Early Pub Date December 24, 2022
Publication Date December 23, 2022
Published in Issue Year 2022Volume: 4 Issue: 1

Cite

APA Gezer, A., & Karadağ Sarı, E. (2022). Ana Hatları ile Ferroptozis. Turkish Veterinary Journal, 4(1), 24-27. https://doi.org/10.51755/turkvetj.1078397
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