Research Article
Year 2020,
Volume: 2 Issue: 2, 67 - 73, 30.12.2020
Abstract
Antik çağlardan beri bitkiler çeşitli hastalıkların tedavisinde kullanılmaktadırlar. Morus alba da eskiden beri başta diabet olmak üzere karaciğer, dalak, immun sistem ve kardiyovasküler sistem kaynaklı pek çok hastalığın tedavisinde geleneksel olarak kullanılmaktadır. Bu çalışmada Morus albanın yara iyileşmesi üzerindeki etkileri araştırılmıştır. Çalışmada Wistar cinsi erkek ratlarda oluşturulan yara modelinde kontrol, dekspantenol (%2,5 ve %5) ve Morus alba ekstraktı (%2,5 ve %5) uygulanmıştır. Çalışma süresince 3, 6, 9, 12 ve 15. günlerde kaliper ile ölçümler yapılıp 15. Günde ratlar ötanazi edilerek histopatolojik değerlendirmeler yapılmıştır. Elde edilen veriler ışığında Morus Alba ekstraktlarının kontrol ve dekspantenol verilenlere göre daha hızlı yara iyileşmesi hızı sağladığını göstermiştir. Sonuç olarak Morus alba ekstraktının yara iyileşmesinde kullanılabileceği kanaatine varılmıştır.
Keywords
Supporting Institution
herhangi bir kurum tarafından desteklenmemiştir
Project Number
-
Thanks
Sivas Cumhuriyet Üniversitesi Tıp Fakültesi Deney Hayvanları Ünitesi sorumlu Veteriner Hekimi Yücel Yalman'a teşekkür ederiz
References
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- Chen P-N, Chu S-C, Chiou H-L, Kuo W-H, Chiang C-L,Hsieh Y-SJCl (2006) Mulberry anthocyanins, cyanidin 3-rutinoside and cyanidin 3-glucoside, exhibited an inhibitory effect on the migration and invasion of a human lung cancer cell line. 235: 248-259.
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- Guo Sa,DiPietro LAJJodr (2010) Factors affecting wound healing. 89: 219-229.
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- Khan MS,Jain PK Anti-ulcerogenic effect of ethanolic extract of fruits in chemically induced Morus alba ulcer.
- Kim KH, Chung WS, Kim Y, Kim KS, Lee IS, Park JY, Jeong HS, Na YC, Lee CH,Jang HJJPR (2015) Transcriptomic analysis reveals wound healing of Morus alba root extract by up‐regulating keratin filament and CXCL12/CXCR4 signaling. 29: 1251-1258.
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- Melissa CJW (1998) Cutaneous wound repair. 10: 12-32.
- Pakyari M, Farrokhi A, Maharlooei MK,Ghahary AJAiwc (2013) Critical role of transforming growth factor beta in different phases of wound healing. 2: 215-224.
- Pastar I, Stojadinovic O, Yin NC, Ramirez H, Nusbaum AG, Sawaya A, Patel SB, Khalid L, Isseroff RR,Tomic-Canic MJAiwc (2014) Epithelialization in wound healing: a comprehensive review. 3: 445-464.
- Regan M,Barbul AJWh (1994) The cellular biology of wound healing. 1: 3-17.
- Rodriguez LG, Wu X,Guan J-L,(2005) Wound-healing assay, In: Cell Migration. Springer,pp 23-29.
- Schreier T, Degen E,Baschong W (1993) Fibroblast migration and proliferation during in vitro wound healing. Research in Experimental Medicine 193: 195-205.
- Shukla R, Kashaw SK, Jain AP,Lodhi SJIjobm (2016) Fabrication of Apigenin loaded gellan gum–chitosan hydrogels (GGCH-HGs) for effective diabetic wound healing. 91: 1110-1119.
- Singer AJ,Clark RA (1999) Cutaneous wound healing. J New England journal of medicine 341: 738-746.
- Spotnitz WD, Falstrom JK,Rodeheaver GTJSC (1997) The role of sutures and fibrin sealant in wound healing. 77: 651-669.
- Swaim SF, Henderson RA,Pidgeon RS,(1990) Small animal wound management. Lea & Febiger.
- Theoret CL JCTiEP (2004) Update on wound repair. 3: 110-122.
- Uyar A, Akyol T, Yaman T,Keleş ÖF, Van Veterinary Journal (2017), A Histopathological and Biochemical Investigation of the Wound Healing and Oxidative Stress Effect on the Wound Model of the Achillea millefolium in Rats. 28(3): 157-163
- Wild T, Rahbarnia A, Kellner M, Sobotka L,Eberlein TJN (2010) Basics in nutrition and wound healing. 26: 862-866.
- Younus I, Fatima A, Ali SM, Usmani S, Begum Z, Badar S, Asghar RJIJoAR,Review (2016) A review of ethnobotany, phytochemistry, antiviral and cytotoxic/anticancer potential of morus alba linn. 1: 84-96.
Year 2020,
Volume: 2 Issue: 2, 67 - 73, 30.12.2020
Abstract
Plants have been used in the treatment of various diseases since ancient times. Morus alba has traditionally been used in the treatment of many diseases originating from the liver, spleen, immune system and cardiovascular system, especially diabetes. In this study, the effects of Morus alba on wound healing were investigated. In the study, dexpanthenol (2.5% and 5%) and Morus alba extract (2.5% and 5%) were applied in the wound model created in male Wistar rats. During the study, measurements were made with calipers on the 3rd, 6th, 9th, 12th and 15th days and the rats were euthanized on the 15th day and histopathological evaluations were made. In the light of the data obtained, it has been shown that Morus Alba extracts provide faster wound healing rate than those given control and dexpanthenol. As a result, it was concluded that Morus alba extract can be used in wound healing.
Keywords
Project Number
-
References
- Asano N, Yamashita T, Yasuda K, Ikeda K, Kizu H, Kameda Y, Kato A, Nash RJ, Lee HS, Ryu KSJJoA,Chemistry F (2001) Polyhydroxylated alkaloids isolated from mulberry trees (Morus alba L.) and silkworms (Bombyx mori L.). 49: 4208-4213.
- Chen P-N, Chu S-C, Chiou H-L, Kuo W-H, Chiang C-L,Hsieh Y-SJCl (2006) Mulberry anthocyanins, cyanidin 3-rutinoside and cyanidin 3-glucoside, exhibited an inhibitory effect on the migration and invasion of a human lung cancer cell line. 235: 248-259.
- Das U, Behera SS,Pramanik KJPR (2017) Ethno‐herbal‐medico in wound repair: An incisive review. 31: 579-590.
- Devi B, Sharma N, Kumar D, Jeet KJIJoP,Sciences P (2013) Morus alba Linn: A phytopharmacological review. 5: 14-18.
- Dey A, Gupta B,De JNJJoMPR (2012) Traditional phytotherapy against skin diseases and in wound healing of the tribes of Purulia district, West Bengal, India. 6: 4825-4483.
- Dorsett‐Martin WA,Regeneration (2004) Rat models of skin wound healing: a review. J Wound Repair 12: 591-599. Efteli EÜ,Güneş Ü, JAHvSBD(2014) Basınç Yarası Gelişiminde Perfüzyon Değerlerinin Etkisi. 17:3 140-144 Eo H,Lim YJJomf (2016) Combined mulberry leaf and fruit extract improved early stage of cutaneous wound healing in high-fat diet-induced obese mice. 19: 161-169. Flanagan MJJowc (2003) Wound measurement: can it help us to monitor progression to healing? 12: 189-194.
- George Broughton I, Janis JE, Attinger CEJP,surgery r (2006) The basic science of wound healing. 117: 12S-34S.
- Guo Sa,DiPietro LAJJodr (2010) Factors affecting wound healing. 89: 219-229.
- Hussain F, Rana Z, Shafique H, Malik A,Hussain ZJAPjotb (2017) Phytopharmacological potential of different species of Morus alba and their bioactive phytochemicals: A review. 7: 950-956.
- Khan MS,Jain PK Anti-ulcerogenic effect of ethanolic extract of fruits in chemically induced Morus alba ulcer.
- Kim KH, Chung WS, Kim Y, Kim KS, Lee IS, Park JY, Jeong HS, Na YC, Lee CH,Jang HJJPR (2015) Transcriptomic analysis reveals wound healing of Morus alba root extract by up‐regulating keratin filament and CXCL12/CXCR4 signaling. 29: 1251-1258.
- Kirsner RS,Eaglstein WHJDc (1993) The wound healing process. 11: 629-640.
- Melissa CJW (1998) Cutaneous wound repair. 10: 12-32.
- Pakyari M, Farrokhi A, Maharlooei MK,Ghahary AJAiwc (2013) Critical role of transforming growth factor beta in different phases of wound healing. 2: 215-224.
- Pastar I, Stojadinovic O, Yin NC, Ramirez H, Nusbaum AG, Sawaya A, Patel SB, Khalid L, Isseroff RR,Tomic-Canic MJAiwc (2014) Epithelialization in wound healing: a comprehensive review. 3: 445-464.
- Regan M,Barbul AJWh (1994) The cellular biology of wound healing. 1: 3-17.
- Rodriguez LG, Wu X,Guan J-L,(2005) Wound-healing assay, In: Cell Migration. Springer,pp 23-29.
- Schreier T, Degen E,Baschong W (1993) Fibroblast migration and proliferation during in vitro wound healing. Research in Experimental Medicine 193: 195-205.
- Shukla R, Kashaw SK, Jain AP,Lodhi SJIjobm (2016) Fabrication of Apigenin loaded gellan gum–chitosan hydrogels (GGCH-HGs) for effective diabetic wound healing. 91: 1110-1119.
- Singer AJ,Clark RA (1999) Cutaneous wound healing. J New England journal of medicine 341: 738-746.
- Spotnitz WD, Falstrom JK,Rodeheaver GTJSC (1997) The role of sutures and fibrin sealant in wound healing. 77: 651-669.
- Swaim SF, Henderson RA,Pidgeon RS,(1990) Small animal wound management. Lea & Febiger.
- Theoret CL JCTiEP (2004) Update on wound repair. 3: 110-122.
- Uyar A, Akyol T, Yaman T,Keleş ÖF, Van Veterinary Journal (2017), A Histopathological and Biochemical Investigation of the Wound Healing and Oxidative Stress Effect on the Wound Model of the Achillea millefolium in Rats. 28(3): 157-163
- Wild T, Rahbarnia A, Kellner M, Sobotka L,Eberlein TJN (2010) Basics in nutrition and wound healing. 26: 862-866.
- Younus I, Fatima A, Ali SM, Usmani S, Begum Z, Badar S, Asghar RJIJoAR,Review (2016) A review of ethnobotany, phytochemistry, antiviral and cytotoxic/anticancer potential of morus alba linn. 1: 84-96.
There are 26 citations in total.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Veterinary Surgery |
| Journal Section | Research Article |
| Authors | |
| Project Number | - |
| Publication Date | December 30, 2020 |
| Published in Issue | Year 2020Volume: 2 Issue: 2 |
