Abstract
Bu çalışmamızda, Kangal ırkı bir köpekte saptanan osteosarkom vakasının histopatolojik ve radyografik açıdan değerlendirilmesi amaçlanmıştır. Çalışmanın materyalini 8 yaşında erkek 50 kg ağırlığında Kangal ırkı bir köpek oluşturdu. Sol ön ekstremitede şişlik, topallık ve solunum güçlüğü şikayetleri ile Kafkas Üniversitesi Veteriner Fakültesi Cerrahi Kliniği'ne getirilen hastanın geçmişine ilişkin bilgi edinilemedi. Klinik muayenede hastanın genel durumunun bozuk olduğu, karpal eklem seviyesinde, sert ve ağrılı bir şişliğin bulunduğu belirlendi. Hastanın yaşlı olması, genel durum bozukluğu ve prognozun kuşkulu görülmesi üzerine ötenazisi yapıldı. Takibinde sistemik nekropsisi gerçekleştirildi. Rutin doku takip işlemlerinin ardından hazırlanan parafin bloklardan, Hematoksilen Eozin boyaması için 5 μm kalınlığında kesitler alındı. Histopatolojik değişikliklerin belirlenmesi amacıyla kesitler ışık mikroskobunda incelendi. Elde edilen radyografik ve histopatolojik bulgular ışığında sol ön ekstremitedeki tümoral kitle ve akciğerdeki metastatik odaklara osteosarkom tanısı konuldu.
Keywords
References
- Altuğ ME, Deveci MZY (2016) Dokularına Göre Tümöral Oluşumlara Cerrahi Yaklaşımlar. Turkiye Klinikleri J Vet Sci Surg-Special Topics 2:70-79.
- Aydoğan A, Metin N (2013) Köpek Yumuşak Doku Tümörlerinde Patolojik Tanı: Derleme. MAKÜ Sag Bil Enst Derg 1:86-105.
- Baştan İ (2013) Köpeklerde Sık Rastlanan Kanser Çeşitleri ve Önemli Klinik Özellikleri. Dicle Üniv Vet Fak Derg 1:25-29.
- Boerman I, Selvarajah GT, Nielen M, Kirpensteijn J (2012) Prognostic factors in canine appendicular osteosarcoma - a meta-analysis. BMC Vet Res 8:56. https://doi.org/10.1186/1746-6148-8-56
- Cristo TG, Vargas CB, Biezus G, Costa LS, Dal Pont TP, Kanamura CT, Salbego FZ, Traverso SD, Casagrande RA (2017) Metastatic osteosarcoma as a cause of hemorrhagic stroke in a dog. Braz J Vet Pathol 10:105-110. https://doi.org/10.24070/bjvp.1983-0246.v10i3p105-110
- Erer H, Elma E, Hatipoğlu H, Alkan F (1998) Kangal Irkı Bir Köpekte Osteosarkom Olgusu. Vet Bil Derg 14:107-112.
- Erer H, Kıran MM (2009) Veteriner Onkoloji. 4.Basım, 110-114, Damla Ofset A.Ş., Konya
- Farese JP, Ashton J, Milner R, Ambrose LL, Van Gilder J (2004) The effect of the bisphosphonate alendronate on viability of canine osteosarcoma cells in vitro. In Vitro Cell Dev Biol Anim 40: 113-117.
- Farjanikish G, Dezfoulian O, Mohammadi H (2018) Metastatic giant cell osteosarcoma in a cat. Vet Res Forum 9:289–292. https://doi.org/10.30466/vrf.2018.32087
- Gebhard C, Fuchs-Baumgartinger A, Razzazi-Fazeli E, Miller I, Walter I (2016) Distribution and activity levels of matrix metalloproteinase 2 and 9 in canine and feline osteosarcoma. Can J Vet Res 80:66-73.
- Güneş V, Atasever A, Atalan G, Onmaz AC (2009) Bir Köpekte Kuyruk Orijinli Metastazik Karsinosarkom Olgusu. F Ü Sağ Bil Vet Derg 23:111-115.
- Hoenerhoff MJ, Kiupel M, Rosenstein D, Pool RR (2004) Multipotential Osteosarcoma with Various Mesenchymal Differentiations in a Young Dog. Vet Pathol 41:264-268.
- Kutsal O, Kaya Ü, Vural S, Sağlam M (2003) Köpek ve Kedilerde 1986-2000 Yılları Arasında Ankara'da İncelenen Kemik Tümörleri. Turk J Vet Anim Sci 27:109-115.
- Leonardo L, Laura P, Serena BM (2018) miR-1 and miR-133b expression in canine osteosarcoma. Res Vet Sci 117:133-137. https://doi.org/10.1016/j.rvsc.2017.12.002
- McNeill CJ, Overley B, Shofer FS, Kent MS, Clifford CA, Samluk M, Haney S, Van Winkle TJ, Sorenmo KU (2007) Characterization of the biological behaviour of appendicular osteosarcoma in Rottweilers and a comparison with other breeds: a review of 258 dogs. Vet Comp Oncol 5:90-98. https://doi.org/10.1111/j.1476-5829.2006.00116.x
- Milli UH, Hazıroğlu R (1997) Veteriner Patoloji. s. 407-411. Tamer Matbaacılık, Ankara.
- Murphy BG, Mok MY, York D, Rebhun R, Woolard KD, Hillman C, Dickinson P, Skorupski K (2017) Evaluation of P16 expression in canine appendicular osteosarcoma. BMC Veterinary Research 13:189. https://doi.org/10.1186/s12917-017-1113-5
- Pazzi P, Tompkins S, Kirberger RM (2013) Canine spirocercosis-associated extraskeletal osteosarcoma with central nervous system metastasis. J S Afr Vet Assoc 84, E1-4. https://doi.org/10.4102/jsava.v84i1.71
- Sarıerler M, Yürekli Y, Güzel N (2003) Clinical, Radiographical, and Histopathological Findings of A Dog with Osteosarcoma. Kafkas Univ Vet Fak Derg 9:203-206.
- Sennazli G, Erdogan O, Devecioglu Y, Inal B (2013) A Case of Telangiectatic Osteosarcoma in a Dog. J Fac Vet Med Istanbul Univ 39:121-125.
- Tez G, Kanca H, Alemdar H (2019) Köpeklerde kontrasepsiyon I: Cerrahi sterilizasyonun risk ve yararlarının değerlendirilmesi. Vet Hekim Der Derg 90:55-65. https://doi.org/10.33188/vetheder.487204
- Thompson KG, Dittmer KE (2017) Tumors of Bone. In: Moulton JE (ed) Tumors of Domestic Animals, 5th edn. Wiley Blackwell, Iowa, pp 356-424
- Wilson H, Huelsmeyer M, Chun R, Young KM, Friedrichs K, Argyle DJ (2008) Isolation and characterisation of cancer stem cells from canine osteosarcoma. Vet J 175:69-75. https://doi.org/10.1016/j.tvjl.2007.07.025
- Withers SS, Skorupski KA, York D, Choi JW, Woolard KD, Laufer-Amorim R, Sparger EE, Rodriguez CO, McSorley SJ, Monjazeb AM, Murphy WJ, Canter RJ, Rebhun RB (2019) Association of macrophage and lymphocyte infiltration with outcome in canine osteosarcoma. Vet Comp Oncol 17:49-60. https://doi.org/10.1111/vco.12444
Abstract
In our study, we aimed to evaluate findings of osteosarcoma detected in a Kangal breed dog for the histopathological and radiographic aspects. The material of the study consisted of a male, 8 years old Kangal breed dog with a weight of 50 kg. There was no information about the history of the patient who was brought to the Surgical Clinic of the Faculty of Veterinary Medicine of Kafkas University with complaints of swelling in the left anterior extremity, lameness and respiratory weakness. Clinical examination revealed that the general condition of the patient was poor and there was a hard and painful swelling at the carpal joint level. Euthanasia was performed due to old age, poor condition and suspicious prognosis. Then, systemic necropsy was performed. After routine tissue follow-up procedures, 5 μm thick sections were taken from paraffin blocks for Hematoxylin Eosin staining. Sections were examined under light microscope to determine the histopathologic changes. Based on radiographic and histopathologic findings of the tumors in the left anterior extremity and metastatic foci in the lung, osteosarcoma was diagnosed.
Keywords
References
- Altuğ ME, Deveci MZY (2016) Dokularına Göre Tümöral Oluşumlara Cerrahi Yaklaşımlar. Turkiye Klinikleri J Vet Sci Surg-Special Topics 2:70-79.
- Aydoğan A, Metin N (2013) Köpek Yumuşak Doku Tümörlerinde Patolojik Tanı: Derleme. MAKÜ Sag Bil Enst Derg 1:86-105.
- Baştan İ (2013) Köpeklerde Sık Rastlanan Kanser Çeşitleri ve Önemli Klinik Özellikleri. Dicle Üniv Vet Fak Derg 1:25-29.
- Boerman I, Selvarajah GT, Nielen M, Kirpensteijn J (2012) Prognostic factors in canine appendicular osteosarcoma - a meta-analysis. BMC Vet Res 8:56. https://doi.org/10.1186/1746-6148-8-56
- Cristo TG, Vargas CB, Biezus G, Costa LS, Dal Pont TP, Kanamura CT, Salbego FZ, Traverso SD, Casagrande RA (2017) Metastatic osteosarcoma as a cause of hemorrhagic stroke in a dog. Braz J Vet Pathol 10:105-110. https://doi.org/10.24070/bjvp.1983-0246.v10i3p105-110
- Erer H, Elma E, Hatipoğlu H, Alkan F (1998) Kangal Irkı Bir Köpekte Osteosarkom Olgusu. Vet Bil Derg 14:107-112.
- Erer H, Kıran MM (2009) Veteriner Onkoloji. 4.Basım, 110-114, Damla Ofset A.Ş., Konya
- Farese JP, Ashton J, Milner R, Ambrose LL, Van Gilder J (2004) The effect of the bisphosphonate alendronate on viability of canine osteosarcoma cells in vitro. In Vitro Cell Dev Biol Anim 40: 113-117.
- Farjanikish G, Dezfoulian O, Mohammadi H (2018) Metastatic giant cell osteosarcoma in a cat. Vet Res Forum 9:289–292. https://doi.org/10.30466/vrf.2018.32087
- Gebhard C, Fuchs-Baumgartinger A, Razzazi-Fazeli E, Miller I, Walter I (2016) Distribution and activity levels of matrix metalloproteinase 2 and 9 in canine and feline osteosarcoma. Can J Vet Res 80:66-73.
- Güneş V, Atasever A, Atalan G, Onmaz AC (2009) Bir Köpekte Kuyruk Orijinli Metastazik Karsinosarkom Olgusu. F Ü Sağ Bil Vet Derg 23:111-115.
- Hoenerhoff MJ, Kiupel M, Rosenstein D, Pool RR (2004) Multipotential Osteosarcoma with Various Mesenchymal Differentiations in a Young Dog. Vet Pathol 41:264-268.
- Kutsal O, Kaya Ü, Vural S, Sağlam M (2003) Köpek ve Kedilerde 1986-2000 Yılları Arasında Ankara'da İncelenen Kemik Tümörleri. Turk J Vet Anim Sci 27:109-115.
- Leonardo L, Laura P, Serena BM (2018) miR-1 and miR-133b expression in canine osteosarcoma. Res Vet Sci 117:133-137. https://doi.org/10.1016/j.rvsc.2017.12.002
- McNeill CJ, Overley B, Shofer FS, Kent MS, Clifford CA, Samluk M, Haney S, Van Winkle TJ, Sorenmo KU (2007) Characterization of the biological behaviour of appendicular osteosarcoma in Rottweilers and a comparison with other breeds: a review of 258 dogs. Vet Comp Oncol 5:90-98. https://doi.org/10.1111/j.1476-5829.2006.00116.x
- Milli UH, Hazıroğlu R (1997) Veteriner Patoloji. s. 407-411. Tamer Matbaacılık, Ankara.
- Murphy BG, Mok MY, York D, Rebhun R, Woolard KD, Hillman C, Dickinson P, Skorupski K (2017) Evaluation of P16 expression in canine appendicular osteosarcoma. BMC Veterinary Research 13:189. https://doi.org/10.1186/s12917-017-1113-5
- Pazzi P, Tompkins S, Kirberger RM (2013) Canine spirocercosis-associated extraskeletal osteosarcoma with central nervous system metastasis. J S Afr Vet Assoc 84, E1-4. https://doi.org/10.4102/jsava.v84i1.71
- Sarıerler M, Yürekli Y, Güzel N (2003) Clinical, Radiographical, and Histopathological Findings of A Dog with Osteosarcoma. Kafkas Univ Vet Fak Derg 9:203-206.
- Sennazli G, Erdogan O, Devecioglu Y, Inal B (2013) A Case of Telangiectatic Osteosarcoma in a Dog. J Fac Vet Med Istanbul Univ 39:121-125.
- Tez G, Kanca H, Alemdar H (2019) Köpeklerde kontrasepsiyon I: Cerrahi sterilizasyonun risk ve yararlarının değerlendirilmesi. Vet Hekim Der Derg 90:55-65. https://doi.org/10.33188/vetheder.487204
- Thompson KG, Dittmer KE (2017) Tumors of Bone. In: Moulton JE (ed) Tumors of Domestic Animals, 5th edn. Wiley Blackwell, Iowa, pp 356-424
- Wilson H, Huelsmeyer M, Chun R, Young KM, Friedrichs K, Argyle DJ (2008) Isolation and characterisation of cancer stem cells from canine osteosarcoma. Vet J 175:69-75. https://doi.org/10.1016/j.tvjl.2007.07.025
- Withers SS, Skorupski KA, York D, Choi JW, Woolard KD, Laufer-Amorim R, Sparger EE, Rodriguez CO, McSorley SJ, Monjazeb AM, Murphy WJ, Canter RJ, Rebhun RB (2019) Association of macrophage and lymphocyte infiltration with outcome in canine osteosarcoma. Vet Comp Oncol 17:49-60. https://doi.org/10.1111/vco.12444
Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Surgery |
| Journal Section | Case Report |
| Authors | |
| Publication Date | August 15, 2019 |
| Published in Issue | Year 2019Volume: 1 Issue: 2 |
