The Effect of Birth Type on Serum Irisin Levels in Awassi Lambs

Tuğra Akkuş; Ömer Yaprakcı; Rüveyda Bayazit; Mehmet Ekici; Ali Coşkun Demirtaş

doi:10.51755/turkvetj.1530723

TR EN

İvesi Irkı Kuzularda Doğum Şeklinin Serum İrisin Düzeylerine Etkisi

Öz

Sunulan çalışmada, İvesi ırkı kuzularda normal doğum ve güç doğumun serum irisin düzeyleri üzerindeki etkisini ortaya koymak amaçlanmıştır. Çalışma materyalini, İvesi ırkı koyunlardan doğan 20 adet kuzu oluşturdu. Çalışmada; alınan anamnezde önceki doğumlarını normal olarak yapmış, doğum sonrası herhangi bir problem şekillenmemiş ve bakılması düşünülen parametrelerin objektif değerlendirilebilmesi için sadece tekiz doğum yapan koyunlar çalışmaya dahil edildi. Doğan kuzular, doğum şekline göre 2 gruba ayrıldı. Grup 1 (n=10) normal doğum sonucu meydana gelen kuzulardan, Grup 2 (n=10) ise güç doğum sonucu meydana gelen kuzulardan oluştu. Her iki çalışma grubundaki kuzulardan; kolostrum alımı öncesinde, kolostrum alımı sonrasında ve postnatal dönemin 15., 30., 45. ve 60. günlerinde (toplam altı kez) vena jugularis’ten kan örneği alınarak santrifüj edildi. Serum İrisin düzeyleri ticari kit kullanılarak değerlendirildi. Elde edilen veriler iki yönlü varyans analizi ile analiz edildi. Grup içi değerlendirmede ise, her iki grup için kolostrum alımı öncesi, kolostrum alımı sonrası ve postnatal dönemin ölçümlerinde zamana bağlı anlamlı farklılıklar gözlemlendi (P<0.001). Ayrıca, serum irisin düzeyinde grup*zaman etkileşiminde de anlamlı farklılık bulundu (P<0.001). Sonuç olarak, doğum şekli ile serum İrisin düzeyi arasında özellikle kolostrum alımı öncesi önemli farklılıklar gözlendi. Yavru beslenmesinde önemli bir yeri olan kolostrumun, özellikle güç doğum olgularında zaman kaybetmeden yavrulara verilmesinin, yenidoğanların hastalıklara karşı korunmasını, hızlı toparlanmasını ve sağlıklı bir başlangıç yapmasını sağladığı sonucuna varıldı.

Anahtar Kelimeler

The Effect of Birth Type on Serum Irisin Levels in Awassi Lambs

Abstract

The present study aims to reveal the effects of normal birth and dystocia on serum irisin levels in Awassi lambs. The study material consisted of 20 lambs born from Awassi sheep. Only sheep that had previously given birth normally, had no postnatal problems, and had single births were included to objectively evaluate the parameters under investigation. The newborn lambs were divided into two groups based on the type of birth. Group 1 (n=10) consisted of lambs born from normal births, while Group 2 (n=10) consisted of lambs born from dystocia. Blood samples were collected from the vena jugularis of lambs in both study groups before colostrum intake, after colostrum intake, and on the 15th, 30th, 45th, and 60th days of the postnatal period (a total of six times) and were then centrifuged. Serum irisin levels were assessed using a commercial kit. The obtained data were analyzed using two-way ANOVA. In the intergroup assessment, the serum irisin level in the dystocia group was found to be higher before colostrum intake (P<0.001). In the within-group assessment, significant time-dependent differences were observed in the measurements before colostrum intake, after colostrum intake, and during the postnatal period for both groups (P<0.001). Additionally, a significant difference was found in the group*time interaction for serum irisin levels (P<0.001). In conclusion, significant differences were observed between birth type and serum irisin levels, particularly before colostrum intake. It was concluded that administering colostrum, which plays a crucial role in neonatal nutrition, to lambs without delay, especially in cases of dystocia, ensures protection against diseases, promotes rapid recovery, and provides a healthy start for the newborns.

Keywords

Supporting Institution

Türkiye Bilimsel ve Teknolojik Araştırma Kurumu (TÜBİTAK) (2209-A)

Project Number

1919B012333371

References

Aladag, T., Mogulkoc, R., & Baltaci, A. K. (2023). Irisin and energy metabolism and the role of irisin on metabolic syndrome. Mini Reviews in Medicinal Chemistry, 23(20), 1942-1958. https://doi.org/10.2174/1389557523666230411105506.
Asakura, H., 2004. Fetal and neonatal thermoregulation. Journal of Nippon Medical School, 71: 360-370. https://doi.org/10.1272/jnms.71.360.
Aydogdu, U., Coskun, A., Yuksel, M., Basbug, O., & Agaoglu, Z. T. (2018). The effect of dystocia on passive immune status, oxidative stress, venous blood gas and acid-base balance in lambs. Small Ruminant Research, 166, 115-120. https://doi.org/10.1016/j.smallrumres.2018.06.006.
Bayraktar, B., & Tekce, E. (2021). Anadolu Merinoslarında İrisin hormon yanıtı üzerine bazı fizyolojik parametrelerin etkisi. Etlik Veteriner Mikrobiyoloji Dergisi, 32(2), 145-150. https://doi.org/10.35864/evmd.954977.
Blum, J. W., & Hammon, H. M. (2000). Colostrum effects on the gastrointestinal tract, and on nutritional, endocrine and metabolic parameters in neonatal calves. Livestock Production Science, 66(2), 151-159. https://doi.org/10.1016/S0301-6226(00)00222-0.
Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., & Spiegelman, B. M. (2012). A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature, 481(7382), 463-468. https://doi.org/10.1038/nature10777.
Camargo, D. G., Yanaka, R., Bovino, F., Bregadioli, T., Mendes, L. C., Peiró, J. R., & Feitosa, F. L. (2012). Blood gas parameters and acid-base balance of kids from normal delivery. Pesquisa Veterinária Brasileira, 32, 09-14. https://doi.org/10.1590/S0100-736X2012001300003.
Cannon, B., & Nedergaard, J. (2004). Brown adipose tissue: Function and physiological significance. Physiological Reviews, 84: 277-359. https://doi.org/10.1152/ physrev.00015.2003.

Dwyer, C. M., Conington, J., Corbiere, F., Holmøy, I. H., Muri, K., Nowak, R., & Gautier, J. M. (2016). Invited review: Improving neonatal survival in small ruminants: Science into practice. Animal, 10(3), 449-459. https://doi.org/10.1017/S1751731115001974.
Joro, R., Korkmaz, A., Lakka, T. A., Uusitalo, A. L. T., & Atalay, M. (2021). Plasma irisin and its associations with oxidative stress in athletes suffering from overtraining syndrome. Physiology international, 107(4), 513-526. https://doi.org/10.1556/2060.2020.00037.
Kajimura, S., Spiegelman, B. M., & Seale, P. (2015). Brown and beige fat: physiological roles beyond heat generation. Cell metabolism, 22(4), 546-559. https://doi.org/10.1016/j.cmet.2015.09.007.
Kızıl, M., Rişvanlı, A., Abay, M., Şafak, T., Kılınç, M. A., Yılmaz, Ö., & Şeker, İ. (2023). Effect of Calf Delivery Mode on İrisin, Asprosin, Leptin, Adiponectin, and İnsulin-Like Growth Factor-1 Levels in Dairy Cattle and their Calves. Pakistan Journal of Zoology, 55(4).
Korta, P., Pocheć, E., & Mazur-Biały, A. (2019). Irisin as a multifunctional protein: Implications for health and certain diseases. Medicina, 55, 485. https://doi.org/10.3390/medicina55080485.
Lidell, M. E., & Enerbäck, S. (2010). Brown adipose tissue—a new role in humans?. Nature Reviews Endocrinology, 6(6), 319-325. https://doi.org/10.1038/nrendo.2010.64.
Nowak, R., & Poindron, P. (2006). From birth to colostrum: early steps leading to lamb survival. Reproduction Nutrition Development, 46(4), 431-446. https://doi.org/10.1051/rnd:2006023.
Ojha, S., Robinson, L., Yazdani, M., Symonds, M.E. & Budge, H. (2013). Brown adipose tissue genes in pericardial adipose tissue of newborn sheep are downregulated by maternal nutrient restriction in late gestation. Pediatric Research, 74: 246-251. https:// doi.org/10.1038/pr.2013.107.
Piccione, G., Borruso, M., Fazio, F., Giannetto, C., & Caola, G. (2007). Physiological parameters in lambs during the first 30 days postpartum. Small Ruminant Research, 72, 57–60. doi: https:// doi.org/10.1016/j.smallrumres.2006.04.002.
Shiels, D., Loughrey, J., Dwyer, C. M., Hanrahan, K., Mee, J. F., & Keady, T. W. (2021). A survey of farm management practices relating to the risk factors, prevalence, and causes of lamb mortality in Ireland. Animals, 12(1), 30. https:// doi.org/10.3390/ani12010030.
Singh, A. K., Brar, P. S., Singla, V. K., Gandotra, V. K., Nayyar, S., & Jindal, R. (2009). Effect of handling different types of dystocia on minerals and biochemical profiles in dairy buffaloes. Veterinary Practice, 10(2), 116-121.
Vannucchi, C. I., Rodrigues, J. A., Silva, L. C. G., Lúcio, C. F., & Veiga, G. A. L. (2012). A clinical and hemogasometric survey of neonatal lambs. Small Ruminant Research, 108(1-3), 107-112. https:// doi.org/10.1016/j.smallrumres.2012.05.013.
Yano, N., Zhao, Y. T., & Zhao, T. C. (2021). The physiological role of irisin in the regulation of muscle glucose homeostasis. Endocrines, 2(3), 266-283. https://doi.org/10.3390/endocrines2030025.
Zhang, X., Zhang, Y., & Shi, X. (2020). The stability of metabolic biomarkers in early postnatal periods and their implications for newborn health monitoring. Pediatric Research, 88(4), 557-564. https:// doi.org/10.3390/ani9040193.

Details

Primary Language

English

Subjects

Veterinary Obstetrics and Gynecology

Journal Section

Research Article

Authors

Tuğra Akkuş ^*
0000-0002-6002-5942
Türkiye

Ömer Yaprakcı
0000-0002-7784-9438
Türkiye

Rüveyda Bayazit
0009-0002-7030-837X
Türkiye

Mehmet Ekici
0000-0002-2163-6214
Türkiye

Ali Coşkun Demirtaş
0000-0003-4036-8582
Türkiye

Early Pub Date

December 28, 2024

Publication Date

December 31, 2024

Submission Date

August 9, 2024

Acceptance Date

December 3, 2024

Published in Issue

Year 2024 Volume: 6 Number: 2

DOI

https://doi.org/10.51755/turkvetj.1530723

IZ

https://izlik.org/JA98DU89CS

Cite

RIS / Bibtex

APA

Akkuş, T., Yaprakcı, Ö., Bayazit, R., Ekici, M., & Demirtaş, A. C. (2024). The Effect of Birth Type on Serum Irisin Levels in Awassi Lambs. Turkish Veterinary Journal, 6(2), 56-60. https://doi.org/10.51755/turkvetj.1530723