Apigenin ve Metabolik Etkileri

Sena Tıraş; Nazlı Ercan; Tevhide Sel

doi:10.51755/turkvetj.1397751

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Apigenin ve Metabolik Etkileri

Öz

Önemli bir bitki içeriği olan flavonoidler, yüzyılı aşkındır bilinmekte ve birçok klinik deneysel çalışmada ilgi çeken bileşiklerin başında gelmektedir. Flavonoidler altı alt sınıfa ayrılmaktadır. Apigenin bu alt sınıflardan flavonlar sınıfına dahildir. Apigenin’i öne çıkaran en önemli özelliği benzer flavonoidlerden daha düşük toksisiteye sahip olmasıdır. Birçok meyve, sebze ve tıbbi bitkiler bol miktarda apigenin içermektedir. Geçmişten beri geleneksel tıpta da bir ilaç olarak kullanılan apigenin’in günümüzde astım, uykusuzluk, zona, nörolojik ve Parkinson gibi birçok hastalığın da tedavisinde de kullanılmaktadır. Apigenin, anti-oksidan, anti-diyabetik, anti-kanser, anti-inflamatuvar, anti-mikrobiyal, anti-genotoksik, anti-anjiyogenik ve hepotaprotektif gibi daha birçok biyolojik ve terapötik potansiyele sahiptir. Fakat, literatür taramaları sonucu diğer flavonoidler ile karşılaştırıldığı zaman apigenin ile ilgili çok fazla çalışma yapılmamış olduğu gözlenmiştir. Buradan yola çıkılarak, bu derlemede apigenin ve bazı hastalıklar üzerindeki etkisi ile ilgili bilgi verilmesi amaçlanmıştır.

Anahtar Kelimeler

References

Ali, F., Rahul, Naz, F., Jyoti, S., & Siddique, Y. H. (2017). Health functionality of apigenin: A review. International Journal of Food Properties, 20(6), 1197-1238. https://doi.org/10.1080/10942912.2016.1207188.
Banerjee, K., & Mandal, M. (2015). Oxidative stress triggered by naturally occurring flavone apigenin results in senescence and chemotherapeutic effect in human colorectal cancer cells. Redox Biology, 5, 153-162.
Barky, A., Ezz, A., & Mohammed, T. (2020). The Potential role of apigenin in diabetes mellitus. Int. J. Clin. Case Rep. Rev, 3(1), 32.
Bi, C. C., Han, W. W., Yu, J. R., Zhang, H. F., Xing, G. Y., & Liu, Z. (2023). Insights into the pharmacological and therapeutic effects of apigenin in liver injuries and diseases. Heliyon, 9(5). https://doi.org/ARTNe1560910.1016/j.heliyon.2023.e15609.
Cazarolli, L. H., Folador, P., Moresco, H. H., Brighente, I. M., Pizzolatti, M. G., & Silva, F. R. (2009). Stimulatory effect of apigenin-6-C-beta-L-fucopyranoside on insulin secretion and glycogen synthesis. Eur J Med Chem, 44(11), 4668-4673. https://doi.org/10.1016/j.ejmech.2009.07.001.
Chiang, L. C., Ng, L. T., Lin, I. C., Kuo, P. L., & Lin, C. C. (2006). Anti-proliferative effect of apigenin and its apoptotic induction in human Hep G2 cells. Cancer letters, 237(2), 207-214.
Costa, A. C. D. F., de Sousa, L. M., dos Santos Alves, J. M., Goes, P., Pereira, K. M. A., Alves, A. P. N. N., ... & Gondim, D. V. (2021). Anti-inflammatory and hepatoprotective effects of quercetin in an experimental model of rheumatoid arthritis. Inflammation, 44(5), 2033-2043.
Coşansu, G. (2015). Diyabet: Küresel bir salgın hastalık. Okmeydanı Tıp Dergisi, 31, 1-6.

Ghițu, A., Schwiebs, A., Radeke, H. H., Avram, S., Zupko, I., Bor, A., ... & Danciu, C. (2019). A comprehensive assessment of apigenin as an antiproliferative, proapoptotic, antiangiogenic and immunomodulatory phytocompound. Nutrients, 11(4), 858.
Gulluce, M., Orhan, F., Yanmis, D., Arasoglu, T., Guvenalp, Z., & Demirezer, L. O. (2015). Isolation of a flavonoid, apigenin 7-O-glucoside, from Mentha longifolia (L.) Hudson subspecies longifolia and its genotoxic potency. Toxicology and industrial health, 31(9), 831-840.
Gupta, S., Afaq, F., & Mukhtar, H. (2001). Selective growth-inhibitory, cell-cycle deregulatory and apoptotic response of apigenin in normal versus human prostate carcinoma cells. Biochemical and biophysical research communications, 287(4), 914-920.
Harborne, J. B., & Williams, C. A. (2000). Advances in flavonoid research since 1992. Phytochemistry, 55(6), 481-504.
Haytowitz, D., Bhagwat, S., Harnly, J., Holden, J., & Gebhardt, S. (2006). Sources of flavonoids in the US diet using USDA’s updated database on the flavonoid content of selected foods. US Department of Agriculture (USDA). Agricultural Research Service, Beltsville Human Nutrition Research Center, Nutrient Data Laboratory and Food Composition Laboratory: Beltsville, MD.
He, Y., Fang, X., Shi, J., Li, X., Xie, M., & Liu, X. (2020). Apigenin attenuates pulmonary hypertension by inducing mitochondria-dependent apoptosis of PASMCs via inhibiting the hypoxia inducible factor 1α–KV1. 5 channel pathway. Chemico-biological interactions, 317, 108942.
Hicks, D. F., Goossens, N., Blas-García, A., Tsuchida, T., Wooden, B., Wallace, M. C., ... & Friedman, S. L. (2017). Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells. Scientific reports, 7(1), 42563.
Hu, J., Li, Z., Xu, L.-t., Sun, A.-j., Fu, X.-y., Zhang, L., Jing, L.-l., Lu, A.-d., Dong, Y.-f., & Jia, Z.-p. (2015). Protective effect of apigenin on ischemia/reperfusion injury of the isolated rat heart. Cardiovascular toxicology, 15(3), 241-249.
Huang, J., Wang, S., Zhu, M., Chen, J., & Zhu, X. (2011). Effects of genistein, apigenin, quercetin, rutin and astilbin on serum uric acid levels and xanthine oxidase activities in normal and hyperuricemic mice. Food and Chemical Toxicology, 49(9), 1943-1947.
Imran, M., Gondal, T. A., Atif, M., Shahbaz, M., Qaisarani, T. B., Mughal, M. H., Salehi, B., Martorell, M., & Sharifi-Rad, J. (2020). Apigenin as an anticancer agent.Phytotherapy Research, 34(8), 1812-1828.https://doi.org/10.1002/ptr.6647.
Kilit, A. C., & Aydemir, D. (2021). Apiin’in Sitotoksik Etkisi. Bilim Armonisi, 4(2), 64-70.
Kim, D.-I., Lee, T.-K., Lim, I.-S., Kim, H., Lee, Y.-C., & Kim, C.-H. (2005). Regulation of IGF-I production and proliferation of human leiomyomal smooth muscle cells by Scutellaria barbata D. Don in vitro: isolation of flavonoids of apigenin and luteolin as acting compounds. Toxicology and applied pharmacology, 205(3), 213-224.
Kim, M.-A., Kang, K., Lee, H.-J., Kim, M., Kim, C. Y., & Nho, C.W. (2014). Apigenin isolated from Daphne genkwaSiebold et Zucc. inhibits 3T3-L1 preadipocytedifferentiation through a modulation of mitotic clonalexpansion. Life sciences, 101(1-2), 64-72.
Kim, S., Woo, E. R., & Lee, D. G. (2020). Apigenin promotes antibacterial activity via regulation of nitric oxide and superoxide anion production. Journal of basic microbiology, 60(10), 862-872.
Kolaç, T., Gürbüz, P., & Yetiş, G. (2017). Doğal ürünlerin fenolik içeriği ve antioksidan özellikleri. İnönü Üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi, 5(1), 26-42.
Liu, H. J., Fan, Y. L., Liao, H. H., Liu, Y., Chen, S., Ma, Z. G., ... & Tang, Q. Z. (2017). Apigenin alleviates STZ-induced diabetic cardiomyopathy. Molecular and cellular biochemistry, 428, 9-21.
Malik, S., Suchal, K., Khan, S. I., Bhatia, J., Kishore, K., Dinda, A. K., & Arya, D. S. (2017). Apigenin ameliorates streptozotocin-induced diabetic nephropathy in rats via MAPK-NF-κB-TNF-α and TGF-β1-MAPK-fibronectin pathways. American Journal of Physiology-Renal Physiology, 313(2), F414-F422.
Moslehi, M., Rezaei, S., Talebzadeh, P., Ansari, M. J., Jawad, M. A., Jalil, A. T., Rastegar-Pouyani, N., Jafarzadeh, E., Taeb, S., & Najafi, M. (2023). Apigenin in cancer therapy: Prevention of genomic instability and anticancer mechanisms. Clinical and Experimental Pharmacology and Physiology, 50(1), 3-18. https://doi.org/10.1111/1440-1681.13725.
Mushtaq, Z., Sadeer, N. B., Hussain, M., Mahwish, Alsagaby, S. A., Imran, M., Mumtaz, T., Umar, M., Tauseef, A., Al Abdulmonem, W., Tufail, T., Al Jbawi, E., & Mahomoodally, M. F. (2023). Therapeutical properties of apigenin: a review on the experimental evidence and basic mechanisms. International Journal of Food Properties, 26(1), 1914-1939. https://doi.org/10.1080/10942912.2023.2236329.
Panda, S., & Kar, A. (2007). Apigenin (4',5,7-trihydroxyflavone) regulates hyperglycaemia, thyroid dysfunction and lipid peroxidation in alloxan-induced diabetic mice. J Pharm Pharmacol, 59(11), 1543-1548. https://doi.org/10.1211/jpp.59.11.0012.
Park, C. H., Min, S. Y., Yu, H. W., Kim, K., Kim, S., Lee, H. J., ... & Park, Y. J. (2020). Effects of apigenin on RBL-2H3, RAW264. 7, and HaCaT cells: anti-allergic, anti-inflammatory, and skin-protective activities. International Journal of Molecular Sciences, 21(13), 4620.
Patel, D., Shukla, S., & Gupta, S. (2007). Apigenin and cancer chemoprevention: progress, potential and promise. International journal of oncology, 30(1), 233-245.
Ren, B., Qin, W., Wu, F., Wang, S., Pan, C., Wang, L., ... & Liang, J. (2016). Apigenin and naringenin regulate glucose and lipid metabolism, and ameliorate vascular dysfunction in type 2 diabetic rats. European journal of pharmacology, 773, 13-23.
Ribeiro, J. C., Antunes, L. M. G., Aissa, A. F., Darin, J. D. a. C., De Rosso, V. V., Mercadante, A. Z., & Bianchi, M. d. L.P. (2010). Evaluation of the genotoxic andantigenotoxic effects after acute and subacutetreatments with açai pulp (Euterpe oleracea Mart.) onmice using the erythrocytes micronucleus test and thecomet assay. Mutation Research/Genetic Toxicologyand Environmental Mutagenesis, 695(1-2), 22-28.
Salehi, B., Venditti, A., Sharifi-Rad, M., Kręgiel, D., Sharifi-Rad, J., Durazzo, A., Martins, N. (2019). The therapeutic potential of apigenin. International journal of molecular sciences, 20(6), 1305.
Sharifiaghdam, Z., Amini, S. M., Dalouchi, F., Behrooz, A. B., & Azizi, Y. (2023). Apigenin-coated gold nanoparticles as a cardioprotective strategy against doxorubicin-induced cardiotoxicity in male rats via reducing apoptosis. Heliyon, 9(3).
Shin, G. C., Kim, C., Lee, J. M., Cho, W. S., Lee, S. G., Jeong, M., Lee, K. (2009). Apigenin-induced apoptosis is mediated by reactive oxygen species and activation of ERK1/2 in rheumatoid fibroblast-like synoviocytes. Chemico-Biological Interactions, 182(1), 29-36.
Shukla, S., MacLennan, G. T., Fu, P., & Gupta, S. (2012). Apigenin attenuates insulin-like growth factor-I signaling in an autochthonous mouse prostate cancer model. Pharmaceutical research, 29, 1506-1517.
Siddique, Y. H., & Afzal, M. (2009). Antigenotoxic effect of apigenin against mitomycin C induced genotoxic damage in mice bone marrow cells. Food and chemical toxicology, 47(3), 536-539.
Singh, J. P. V., Selvendiran, K., Banu, S. M., Padmavathi, R., & Sakthisekaran, D. (2004). Protective role of Apigenin on the status of lipid peroxidation and antioxidant defense against hepatocarcinogenesis in Wistar albino rats. Phytomedicine, 11(4), 309-314.
Singh, S. K., Singh, S. K., & Singh, A. (2013). Toxicological and biochemical alterations of apigenin extracted from seed of Thevetia peruviana, a medicinal plant. J Biol Earth Sci, 3(1), 110-119.
Söylemezoğlu, G. (2003). Üzümde fenolik bileşikler. Gıda, 28(3).
Susam, S., & Çıkım, G. (2023). Apigenin'in potansiyel farmakolojik etkileri üzerine bir derleme. Arşiv Kaynak Tarama Dergisi, 32(2).
Şirin, N., Elmas, L., Seçme, M., & Dodurga, Y. (2020). Investigation of possible effects of apigenin, sorafenib and combined applications on apoptosis and cell cycle in hepatocellular cancer cells. Gene, 737, 144428. https://doi.org/10.1016/j.gene.2020.144428.
Thomas, S. D., Jha, N. K., Jha, S. K., Sadek, B., & Ojha, S. (2023). Pharmacological and Molecular Insight on the Cardioprotective Role of Apigenin. Nutrients, 15(2), 385.
Tomou, E. M., Papakyriakopoulou, P., Skaltsa, H., Valsami, G., & Kadoglou, N. P. (2023). Bio-actives from natural products with potential cardioprotective properties: isolation, identification, and pharmacological actions of apigenin, quercetin, and silibinin. Molecules, 28(5), 2387.
Tsai, C.-H., Lin, F.-M., Yang, Y.-C., Lee, M.-T., Cha, T.-L., Wu, G.-J., Hsieh, S.-C., & Hsiao, P.-W. (2009). Herbal extract of Wedelia chinensis attenuates androgen receptor activity and orthotopic growth of prostate cancer in nude mice. Clinical Cancer Research, 15(17), 5435-5444.
Vazhappilly, C. G., Amararathna, M., Cyril, A. C., Linger, R., Matar, R., Merheb, M., Ramadan, W. S., Radhakrishnan, R., & Rupasinghe, H. V. (2021). Current methodologies to refine bioavailability, delivery, and therapeutic efficacy of plant flavonoids in cancer treatment. The Journal of Nutritional Biochemistry, 94, 108623.
Wang, J., Liu, Y. T., Xiao, L., Zhu, L., Wang, Q., & Yan, T. (2014). Anti-inflammatory effects of apigenin in lipopolysaccharide-induced inflammatory in acute lung injury by suppressing COX-2 and NF-kB pathway. Inflammation, 37, 2085-2090.
Yoon, J. H., Kim, M. Y., & Cho, J. Y. (2023). Apigenin: A Therapeutic Agent for Treatment of Skin Inflammatory Diseases and Cancer. International Journal of Molecular Sciences, 24(2), 1498.
Yue, S., Xue, N., Li, H., Huang, B., Chen, Z., & Wang, X. (2020). Hepatoprotective effect of apigenin against liver injury via the non-canonical NF-κB pathway in vivo and in vitro. Inflammation, 43, 1634-1648.
Zare, M. F. R., Rakhshan, K., Aboutaleb, N., Nikbakht, F., Naderi, N., Bakhshesh, M., & Azizi, Y. (2019). Apigenin attenuates doxorubicin induced cardiotoxicity via reducing oxidative stress and apoptosis in male rats. Life sciences, 232, 116623.
Zhang, K., Song, W., Li, D., & Jin, X. (2017). Apigenin in the regulation of cholesterol metabolism and protection of blood vessels. Experimental and Therapeutic Medicine, 13(5), 1719-1724.
Zhang, S., Liu, X., Sun, C., Yang, J., Wang, L., Liu, J., Jing, Y. (2016). Apigenin attenuates experimental autoimmune myocarditis by modulating Th1/Th2 cytokine balance in mice. Inflammation, 39(2), 678-686.
Zhao, G., Qin, G.-W., Wang, J., Chu, W.-J., & Guo, L.-H. (2010). Functional activation of monoamine transporters by luteolin and apigenin isolated from the fruit of Perilla frutescens (L.) Britt. Neurochemistry international, 56(1), 168-176.
Zhao, L., Wang, J. L., Liu, R., Li, X. X., Li, J. F., & Zhang, L. (2013). Neuroprotective, anti-amyloidogenic and neurotrophic effects of apigenin in an Alzheimer’s disease mouse model. Molecules, 18(8), 9949-9965

Details

Primary Language

Turkish

Subjects

Veterinary Biochemistry

Journal Section

Review

Authors

Sena Tıraş ^*
0000-0001-5142-2922
Türkiye

Nazlı Ercan
0000-0003-3542-3743
Türkiye

Tevhide Sel
0000-0002-9753-779X
Türkiye

Early Pub Date

December 27, 2023

Publication Date

December 31, 2023

Submission Date

November 29, 2023

Acceptance Date

December 21, 2023

Published in Issue

Year 1970 Volume: 5 Number: 2

DOI

https://doi.org/10.51755/turkvetj.1397751

IZ

https://izlik.org/JA82YH79NL

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RIS / Bibtex

APA

Tıraş, S., Ercan, N., & Sel, T. (2023). Apigenin ve Metabolik Etkileri. Turkish Veterinary Journal, 5(2), 58-65. https://doi.org/10.51755/turkvetj.1397751

Apigenin and Metabolic Effects

Apigenin ve Metabolik Etkileri

Öz

Anahtar Kelimeler

Apigenin and Metabolic Effects

Abstract

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References

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Primary Language

Subjects

Journal Section

Authors

Early Pub Date

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite