Research Article
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Year 2022, Volume: 1 Issue: 2, 10 - 16, 31.12.2022

Duygu Durna Çorum Orhan Çorum Ayşe Er Kamil Üney

Abstract

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yok

References

  • Antunes, S.A., Teixeira, M.C.B., & Júnior, A.G. (2008). Pentoxifylline effects on the resistant anemia to erythropoietin in hemodialysis patients. Revista Brasileira de Hematologia e Hemoterapia, 30(4), 303-308.
  • Chalmeh, A., Rahmani Shahraki, A., Heidari, S.M., Badiei, K., Paurjafar, M., Nazifi, S., & Zamiri, M.J. (2016). The comparative efficacy of tyloxapol versus pentoxifylline against induced acute phase response in an ovine experimental endotoxemia model. Inflammopharmacology, 24, 59-64.
  • Cioboată, R., Găman, A., Traşcă, D., Ungureanu, A., Docea, A.O., Tomescu, P., Gherghina, F., Arsene, A.L., Badiu, C., Tsatsakis, A.M., Spandidos, D.A., Drakoulis, N., & Călina, D. (2017). Pharmacological management of non-alcoholic fatty liver disease: Atorvastatin versus pentoxifylline. Experimental and Therapeutic Medicine, 13, 2375-2381.
  • Cooper, A., Mikhail, A., Lethbridge, M.W., Kemeny, D.M., & Macdougall, I.C. (2004). Pentoxifylline improves hemoglobin levels in patients with erythropoietin-resistant anemia in renal failure. Journal of the American Society of Nephrology, 15, 1877-1882.
  • Corum, O., Corum, D.D., Atik, O., Er, A., & Uney, K. (2019). Pharmacokinetics of pentoxifylline and its 5- hydroxyhexyl metabolite after intravenous administration of increasing doses to sheep. American Journal of Veterinary Research, 80(7), 702-708.
  • Corum, O., Dik, B., Bahcivan, E., Eser, H., Er, A., & Yazar, E. (2016). Cardiac safety of gamithromycin in ewes. Eurasian Journal of Veterinary Sciences, 32, 242-245.
  • Corum, O., Er, A., Dik, B., Eser, H., Bahcivan, E., & Yazar, E. (2015). Determination of the safety of tulathromycin in sheep. Eurasian Journal of Veterinary Sciences, 31(3), 152-157.
  • Corum, O., Ozdemir, O., Hitit, M., Corum, D.D., Coskun, D., & Er, A. (2018). Pentoxifylline may restore kanamycin-induced renal damage in rats. Acta Scientiae Veterinariae, 46(1), 1-7.
  • Corum, O., Uney, K., Er, A., & Durna Corum, D., (2022). The effect of cefquinome on hematological and biochemical parameters following repeated subcutaneous administrations in sheep. Veterinary Journal of Kastamonu University, 1(1), 1-7.
  • Coskun, D., Cetin, G., & Corum, O. (2022). Effect of ascending doses of pentoxifylline administration on biochemical and hematological parameters in goats. Kocatepe Veterinary Journal, 15(1), 63-68.
  • De Boever, S., Baert, K., De Backer, P., & Croubels, S. (2005). Pharmacokinetics and oral bioavailability of pentoxyfylline in broiler chickens. Journal of Veterinary Pharmacology and Therapeutics, 28(6), 575-580.
  • El-Haggar, S.M., & Mostafa, T.M. (2015). Comparative clinical study between the effect of fenofibrate alone and its combination with pentoxifylline on biochemical parameters and liver stiffness in patients with non-alcoholic fatty liver disease. Hepatology International, 9, 471-479.
  • Golbasi, I., Turkay, C., Timuragaoglu, A., Ozdem, S.S., Belgi, A., Akbas, H., & Bayezid, O. (2003). The effect of pentoxifylline on haemolysis in patients with double cardiac prosthetic valves. Acta Cardiologica, 58(5), 379-383.
  • Jalili, C., Moradi, D., Roshankhah, S., & Salahshoor, M.R. (2019). Effect of pentoxifylline on kidney damage induced by nitrosamine inmale rats. Research in Pharmaceutical Sciences, 14(1), 64-73.
  • Kerr, M.G. (2002a). Clinical biochemistry. In: John Wiley & Sons (Ed.), Veterinary laboratory medicine, (2nd ed., pp: 50-198). Blackwell Science.
  • Kerr, M.G. (2002b). Haematology, In: John Wiley & Sons (Ed.), Veterinary Laboratory Medicine, (2nd ed., pp: 1-68). Blackwell Science.
  • Lepherd, M.L., Canfield, P.J., Hunt, G.B., Bosward, K.L. (2009). Haematological, biochemical and selected acute phase protein reference intervals for weaned female Merino lambs. Australian Veterinary Journal, 87(1), 5-11.
  • Liska, D.A., Akucewich, L.H., Marsella, R., Maxwell, L.K., Barbara, J.E., & Cole, C.A. (2006). Pharmacokinetics of pentoxifylline and its 5-hydroxyhexyl metabolite after oral and intravenous administration of pentoxifylline to healthy adult horses. American Journal of Veterinary Research, 67(9), 1621-1627.
  • Ogura, H., Cioffi, W.G., Okerberg, C.V., Johnson, A.A., Guzman, R.F., Mason, A.D., & Pruitt, B.A. (1994). The effects of pentoxifylline on pulmonary function following smoke inhalation. Journal of Surgical Research, 56, 242-250.
  • Rees, C.A., Boothe, D.M., Boeckh, A., Wilkie, S., Esparza, T., & Green, R. (2003). Dosing regimen and hematologic effects of pentoxifylline and its active metabolites in normal dogs. Veterinary Therapeutics: Research in Applied Veterinary Medicine, 4(2), 188-196.
  • Samlaska, C.P., & Winfield, E.A. (1994). Pentoxifylline. Journal of the American Academy of Dermatology, 30(4), 603-621.
  • Sezik, M., Koker, A., Ozmen, O., Halıguur, M., Kasıkcı, D., Aydogan, A., & Ozatik, O. (2020). Antenatal pentoxifylline therapy to prevent endotoxin induced fetal injury in the preterm goat model. Turkish Journal Of Obstetrics And Gynecology, 17, 259-269.
  • Shahbazian, H., Ghorbani, A., Zafar-Mohtashami, A., Balali, A., AleAli, A., & Lashkarara, G.R. (2017). Administration of pentoxifylline to improve anemia of hemodialysis patients. Journal of Renal Injury Prevention, 6(1), 61-64.
  • Sigurdsson, G.H., & Youssef, H. (1993). Effects of pentoxifylline on hemo- dynamics, gas exchange and multiple organ platelet sequestration in experimental endotoxic shock. Acta Anaesthesiol Scand, 37, 396-403.
  • Sykes, J.E., & Papich, M.G. (2014). Antiviral and immunomodulatory drugs. In: J.E. Sykes. (Ed.), Canine and feline infectious diseases. (1st ed., pp.54-65). Saunders.
  • Tálosi, G., Németh, I., & Pintér, S. (2001). Inhibitory effects of methylxanthines on the preeclamptic-like symptoms in ewes. European Journal of Obstetrics & Gynecology and Reproductive Biology, 99, 25-32.
  • Turgut, K. (2000). Liver tests. In: Veterinary Clinic Laboratory Diagnosis, (1st ed., pp.202-257). Bahcivanlar Press.
  • Uney, K., Tras, B., Corum, O., Yildiz, R., & Maden, M. (2019). Pharmacokinetics of pentoxifylline and its 5- hydroxyhexyl metabolite following intravenous administration in cattle. Tropical Animal Health and Production, 51(2), 435-441.

The effect of pentoxifylline administration at different doses on hematological and biochemical parameters in sheep

Year 2022, Volume: 1 Issue: 2, 10 - 16, 31.12.2022

Duygu Durna Çorum Orhan Çorum Ayşe Er Kamil Üney

Abstract

The aim of the present study was to determine the effect of administration of single increasing doses of pentoxifylline on biochemical and hematological parameters in sheep. The study was carried out on six healthy Merino sheep. Pentoxifylline was given to sheep intravenously at doses of 10, 20, and 40 mg/ kg. Blood samples were taken from the jugular vein before (0 hour) and after (12 hour) pentoxifylline administration. Biochemical parameters such as creatine kinase, albumin, blood urea nitrogen, creatinine, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, gamma glutamyltransferase, cholesterol, triglyceride, total bilirubin and total protein were measured in autoanalyzer. Hematological parameters such as hemoglobin, hematocrit, platelet, red blood cells and white blood cells were determined in blood cell counter. Hematological parameters did not alter between the groups, although it was found that the hematocrit value in 20 mg/ kg dosage group dropped. There were no significant changes in biochemical values following administration of the pentoxifylline at all dose level. These results show that pentoxifylline does not cause significant changes in biochemical and hematological parameters in sheep after intravenous administration at different doses. However, the safety study on pentoxifylline is also also necessary for multiple ascending doses in sheep.

Keywords

Biochemical hematological sheep pentoxifylline.

References

  • Antunes, S.A., Teixeira, M.C.B., & Júnior, A.G. (2008). Pentoxifylline effects on the resistant anemia to erythropoietin in hemodialysis patients. Revista Brasileira de Hematologia e Hemoterapia, 30(4), 303-308.
  • Chalmeh, A., Rahmani Shahraki, A., Heidari, S.M., Badiei, K., Paurjafar, M., Nazifi, S., & Zamiri, M.J. (2016). The comparative efficacy of tyloxapol versus pentoxifylline against induced acute phase response in an ovine experimental endotoxemia model. Inflammopharmacology, 24, 59-64.
  • Cioboată, R., Găman, A., Traşcă, D., Ungureanu, A., Docea, A.O., Tomescu, P., Gherghina, F., Arsene, A.L., Badiu, C., Tsatsakis, A.M., Spandidos, D.A., Drakoulis, N., & Călina, D. (2017). Pharmacological management of non-alcoholic fatty liver disease: Atorvastatin versus pentoxifylline. Experimental and Therapeutic Medicine, 13, 2375-2381.
  • Cooper, A., Mikhail, A., Lethbridge, M.W., Kemeny, D.M., & Macdougall, I.C. (2004). Pentoxifylline improves hemoglobin levels in patients with erythropoietin-resistant anemia in renal failure. Journal of the American Society of Nephrology, 15, 1877-1882.
  • Corum, O., Corum, D.D., Atik, O., Er, A., & Uney, K. (2019). Pharmacokinetics of pentoxifylline and its 5- hydroxyhexyl metabolite after intravenous administration of increasing doses to sheep. American Journal of Veterinary Research, 80(7), 702-708.
  • Corum, O., Dik, B., Bahcivan, E., Eser, H., Er, A., & Yazar, E. (2016). Cardiac safety of gamithromycin in ewes. Eurasian Journal of Veterinary Sciences, 32, 242-245.
  • Corum, O., Er, A., Dik, B., Eser, H., Bahcivan, E., & Yazar, E. (2015). Determination of the safety of tulathromycin in sheep. Eurasian Journal of Veterinary Sciences, 31(3), 152-157.
  • Corum, O., Ozdemir, O., Hitit, M., Corum, D.D., Coskun, D., & Er, A. (2018). Pentoxifylline may restore kanamycin-induced renal damage in rats. Acta Scientiae Veterinariae, 46(1), 1-7.
  • Corum, O., Uney, K., Er, A., & Durna Corum, D., (2022). The effect of cefquinome on hematological and biochemical parameters following repeated subcutaneous administrations in sheep. Veterinary Journal of Kastamonu University, 1(1), 1-7.
  • Coskun, D., Cetin, G., & Corum, O. (2022). Effect of ascending doses of pentoxifylline administration on biochemical and hematological parameters in goats. Kocatepe Veterinary Journal, 15(1), 63-68.
  • De Boever, S., Baert, K., De Backer, P., & Croubels, S. (2005). Pharmacokinetics and oral bioavailability of pentoxyfylline in broiler chickens. Journal of Veterinary Pharmacology and Therapeutics, 28(6), 575-580.
  • El-Haggar, S.M., & Mostafa, T.M. (2015). Comparative clinical study between the effect of fenofibrate alone and its combination with pentoxifylline on biochemical parameters and liver stiffness in patients with non-alcoholic fatty liver disease. Hepatology International, 9, 471-479.
  • Golbasi, I., Turkay, C., Timuragaoglu, A., Ozdem, S.S., Belgi, A., Akbas, H., & Bayezid, O. (2003). The effect of pentoxifylline on haemolysis in patients with double cardiac prosthetic valves. Acta Cardiologica, 58(5), 379-383.
  • Jalili, C., Moradi, D., Roshankhah, S., & Salahshoor, M.R. (2019). Effect of pentoxifylline on kidney damage induced by nitrosamine inmale rats. Research in Pharmaceutical Sciences, 14(1), 64-73.
  • Kerr, M.G. (2002a). Clinical biochemistry. In: John Wiley & Sons (Ed.), Veterinary laboratory medicine, (2nd ed., pp: 50-198). Blackwell Science.
  • Kerr, M.G. (2002b). Haematology, In: John Wiley & Sons (Ed.), Veterinary Laboratory Medicine, (2nd ed., pp: 1-68). Blackwell Science.
  • Lepherd, M.L., Canfield, P.J., Hunt, G.B., Bosward, K.L. (2009). Haematological, biochemical and selected acute phase protein reference intervals for weaned female Merino lambs. Australian Veterinary Journal, 87(1), 5-11.
  • Liska, D.A., Akucewich, L.H., Marsella, R., Maxwell, L.K., Barbara, J.E., & Cole, C.A. (2006). Pharmacokinetics of pentoxifylline and its 5-hydroxyhexyl metabolite after oral and intravenous administration of pentoxifylline to healthy adult horses. American Journal of Veterinary Research, 67(9), 1621-1627.
  • Ogura, H., Cioffi, W.G., Okerberg, C.V., Johnson, A.A., Guzman, R.F., Mason, A.D., & Pruitt, B.A. (1994). The effects of pentoxifylline on pulmonary function following smoke inhalation. Journal of Surgical Research, 56, 242-250.
  • Rees, C.A., Boothe, D.M., Boeckh, A., Wilkie, S., Esparza, T., & Green, R. (2003). Dosing regimen and hematologic effects of pentoxifylline and its active metabolites in normal dogs. Veterinary Therapeutics: Research in Applied Veterinary Medicine, 4(2), 188-196.
  • Samlaska, C.P., & Winfield, E.A. (1994). Pentoxifylline. Journal of the American Academy of Dermatology, 30(4), 603-621.
  • Sezik, M., Koker, A., Ozmen, O., Halıguur, M., Kasıkcı, D., Aydogan, A., & Ozatik, O. (2020). Antenatal pentoxifylline therapy to prevent endotoxin induced fetal injury in the preterm goat model. Turkish Journal Of Obstetrics And Gynecology, 17, 259-269.
  • Shahbazian, H., Ghorbani, A., Zafar-Mohtashami, A., Balali, A., AleAli, A., & Lashkarara, G.R. (2017). Administration of pentoxifylline to improve anemia of hemodialysis patients. Journal of Renal Injury Prevention, 6(1), 61-64.
  • Sigurdsson, G.H., & Youssef, H. (1993). Effects of pentoxifylline on hemo- dynamics, gas exchange and multiple organ platelet sequestration in experimental endotoxic shock. Acta Anaesthesiol Scand, 37, 396-403.
  • Sykes, J.E., & Papich, M.G. (2014). Antiviral and immunomodulatory drugs. In: J.E. Sykes. (Ed.), Canine and feline infectious diseases. (1st ed., pp.54-65). Saunders.
  • Tálosi, G., Németh, I., & Pintér, S. (2001). Inhibitory effects of methylxanthines on the preeclamptic-like symptoms in ewes. European Journal of Obstetrics & Gynecology and Reproductive Biology, 99, 25-32.
  • Turgut, K. (2000). Liver tests. In: Veterinary Clinic Laboratory Diagnosis, (1st ed., pp.202-257). Bahcivanlar Press.
  • Uney, K., Tras, B., Corum, O., Yildiz, R., & Maden, M. (2019). Pharmacokinetics of pentoxifylline and its 5- hydroxyhexyl metabolite following intravenous administration in cattle. Tropical Animal Health and Production, 51(2), 435-441.
There are 28 citations in total.

Details

Primary Language English
Subjects Veterinary Surgery
Journal Section Research Articles
Authors

Duygu Durna Çorum 0000-0003-1567-991X

Orhan Çorum 0000-0003-3168-2510

Ayşe Er 0000-0002-6900-0055

Kamil Üney 0000-0002-8674-4873

Publication Date December 31, 2022
Submission Date November 23, 2022
Published in Issue Year 2022 Volume: 1 Issue: 2

Cite

APA Durna Çorum, D., Çorum, O., Er, A., Üney, K. (2022). The effect of pentoxifylline administration at different doses on hematological and biochemical parameters in sheep. Veterinary Journal of Kastamonu University, 1(2), 10-16.
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