Research Article
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Year 2023, Volume: 8 Issue: 2, 112 - 120, 30.08.2023
https://doi.org/10.31797/vetbio.1293543

Abstract

References

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  • Badgujar, P.C., Pawar, N.N., Chandratre, G.A., Telang, A.G., Sharma, A.K. (2015). Fipronil induced oxidative stress in kidney and brain of mice: protective effect of vitamin E and vitamin C. Pesticide Biochemistry and Physiology, 118, 10-18. https://doi.org/10.1016/j.pestbp.2014.10.013
  • Baxter, R.A. (2008). Anti-aging properties of resveratrol: Review and report of a potent new antioxidant skin care formulation. Journal of Cosmetic Dermatology, 7, 2–7.
  • Bhatt, J.K., Thomas, S., Nanjan, M.J. (2012). Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus. Nutrition Research, 32(7), 537-541. https://doi.org/10.1016/j.nutres.2012.06.003
  • Carbo´, N., Costelli, P., Baccino, F.M., Lo´pez-Soriano, F.J., Argile´s, J.M. (1999). Resveratrol, a natural product present in wine, decreases tumor growth in a rat tumor model. Biochemical and Biophysical Research Communications, 254(3), 739–743. https://doi.org/10.1006/bbrc.1998.9916
  • Chand, N., Naz, S., Rehman, Z., Khan, R.U. (2018). Blood biochemical profile of four fast-growing broiler strains under high ambient temperature. Applied Biological Chemistry, 61(3), 273-279. https://doi.org/10.1007/s13765-018-0358-4
  • Comba, B., Cinar, A., Comba, A., Gencer, Y.G. (2016). Effects of ACTH application on kidney function tests, the electrolytes and hematological parameters in rats. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 63(3), 229-233.
  • Dal-Pan, A., Blanc, S., Aujard, F. (2010). Resveratrol suppresses body mass gain in a seasonal non-human primate model of obesity. BMC Physiology, 10(11). https://doi.org/10.1186/1472-6793-10-11
  • Frankel, E.N., Waterhouse, A.L., Kinsella, J.E. (1993). Inhibition of human LDL oxidation by resveratrol. Lancet, 341(8852), 1103-1104. https://doi.org/10.1016/0140-6736(93)92472-6
  • Ghanim, H., Sia, C.L., Abuaysheh, S., Korzeniewski, K., Patnaik, P., Marumganti, A., Chaudhuri, A., Dandona, P. (2010). An antiinflammatory and reactive oxygen species suppressive effect of an extract of Polygonum cuspidatum containing resveratrol. Journal of Clinical Endocrinology and Metabolism, 95(9), E1-E8. https://doi.org/10.1210/jc.2010-0482
  • Ghasemi, H.A., Nari, N. (2020). Effect of supplementary betaine on growth performance, blood biochemical profile, and immune response in heat-stressed broilers fed different dietary protein levels. Journal of Applied Poultry Research, 29(2), 301-313. https://doi.org/10.1016/j.japr.2019.11.004
  • Harada, N., Zhao, J., Kurihara, H., Nakagata, N., Okajima, K. (2011). Resveratrol improves cognitivefunction in mice by increasing production of insulin-like growth factor-I in the hippocampus. Journal of Nutritional Biochemistry, 22(12), 1150-1159. https://doi.org/10.1016/j.jnutbio.2010.09.016 Hausenblas, H.A., Schoulda, J.A., Smoliga, J.M., Schoulda, S. (2014). Resveratrol treatment as an adjunct to pharmacological management in type 2 diabetes mellitus-systematic review and meta-analysis. Molecular Nutrition and Food Research, 59(1), 147-159. https://doi.org/10.1002/mnfr.201400173 He, S., Li, S., Arowolo, M.A., Yu, Q., Chen, F., Hu, R., He, J. (2019). Effect of resveratrol on growth performance; rectal temperature and serum parameters of yellow‐feather broilers under heat stress. Animal Science Journal, 90(3), 401-411. https://doi.org/10.1111/asj.13161
  • Helkin, A., Stein, J.J., Lin, S., Siddiqui, S., Maier, K.G., Gahtan, V. (2016). Dyslipidemia part 1-review of lipid metabolism and vascular cell physiology. Vascular and Endovascular Surgery, 50(2), 107-118. https://doi.org/10.1177/1538574416628654
  • Hong, H.J., Kang, W., Kim, D.G., Lee, D.H., Lee, Y., Han, C. (2014). Effects of resveratrol on the insulin signaling pathway of obese mice. Journal of Veterinary Science, 15(2), 179-185. https://doi.org/10.4142/jvs.2014.15.2.179
  • Hu, H., Bai, X., Xu, K., Zhang, C., Chen, L. (2021). Effect of phloretin on growth performance, serum biochemical parameters and antioxidant profile in heat-stressed broilers. Poultry Science 100(8), 101217. https://doi.org/10.1016/j.psj.2021.101217
  • Jiang, Z., Wan, Y., Li, P., Xue, Y., Cui, W., Chen, Q., Mao, D. (2019). Effect of curcumin supplement in summer diet on blood metabolites, antioxidant status, immune response, and testicular gene expression in Hu sheep. Animals, 9(10), 720. https://doi.org/10.3390/ani9100720
  • Joe, A.K., Liu, H., Suzui, M., Vural, M.E., Xiao, D., Weinstein, I.B. (2002). Resveratrol induces growth inhibition, S-phase arrest, apoptosis, and changes in biomarker expression in several human cancer cell lines. Clinical Cancer Research, 8(3), 893–903.
  • Juan, M.E., Vinardell, M.P., Planas, J.M. (2002). The daily oral administration of high doses of trans-resveratrol to rats for 28 days is not harmful. Journal of Nutrition, 132, 257-260. https://doi.org/10.1093/jn/132.2.257
  • Khan, M.A., Chen, H.C., Wan, X.X., Tania, M., Xu, A.H., Chen, F.Z., Zhang, D.Z. (2013). Regulatory effects of resveratrol on antioxidant enzymes: A mechanism of growth inhibition and apoptosis induction in cancer cells. Molecular Cell, 35(3), 219-225. https://doi.org/10.1007/s10059-013-2259-z
  • Lee, E.S., Shin, M.O., Yoon, S., Moon, J.O. (2010). Resveratrol inhibits dimethylnitrosamine-induced hepatic fibrosis in rats. Archives of Pharmacal Research, 33, 925-932. https://doi.org/10.1007/s12272-010-0616-4
  • Liu, G.S., Zhang, Z.S., Yang, B., He, W. (2012). Resveratrol attenuates oxidative damage and ameliorates cognitive impairment in the brain of senescence-accelerated mice. Life Science, 91(17-18), 872–877. https://doi.org/10.1016/j.lfs.2012.08.033
  • Liu, L.L., He, J.H., Xie, H.B., Yang, Y.S., Li, J.C., Zou, Y. (2014). Resveratrol induces antioxidant and heat shock protein mRNA expression in response to heat stress in black-boned chickens. Poultry Science, 93(1), 54-62. https://doi.org/10.3382/ps.2013-03423
  • Moreno, M., Castro, E., Falqué, E. (2008). Evolution of trans- and cis- resveratrol content in red grapes (Vitis vinifera L. cv Menciá; Albarello and Merenzao) during ripening. European Food Research and Technology, 227(3), 667-674. https://doi.org/10.1007/s00217-007-0770-1
  • Mossa, A.T.H., Swelam, E.S., Mohafrash, S.M. (2015). Sub-chronic exposure to fipronil induced oxidative stress, biochemical and histopathological changes in the liver and kidney of male albino rats. Toxicology Reports, 2, 775-784. https://doi.org/10.1016/j.toxrep.2015.02.009
  • Nigdikar, S.V., Williams, N.R., Griffin, B.A., Howard, A.N. (1998). Consumption of red wine polyphenols reduces the susceptibility of low-density lipoproteins to oxidation in vivo. American Journal of Clinical Nutrition, 68(2), 258-265. https://doi.org/10.1093/ajcn/68.2.258
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  • NRC (1994). Nutrient Requirements of Poultry. 9th Edn., National Academy Press, Washington, DC. USA.
  • OECD (Organization for Economic Cooperation and Development). (1995). Guidelines for testing chemicals. Repeated dose 28-d oral toxicity study in rodents, No. 407. Paris, France.
  • Ölmez, M., Şahin, T., Makav, M., Karadağoğlu, Ö. (2020). Effect of resveratrol supplemented to japanese quail (Coturnix coturnix japonica) rations on performance and some biochemical parameters. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 26(6), 807-812. https://doi.org/10.9775/kvfd.2020.24542
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  • Poulsen, M.M., Jorgensen, J.O., Jessen, N., Richelsen, B., Pedersen, S.B. (2013). Resveratrol in metabolic health: An overview of the current evidence and perspectives. Annals of the New York Academy of Sciences, 1290(1), 74-82. https://doi.org/10.1111/ nyas.12141
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  • Shankar, S., Singh, G., Srivastava, R.K. (2007). Chemoprevention by resveratrol: molecular mechanisms and therapeutic potential. Frontiers in Bioscience – Landmark, 12(12), 4839-4854. https://doi.org/10.2741/2432
  • Singh, C.K., Ndiaye, M.A., Ahmad, N. (2015). Resveratrol and cancer: Challenges for clinical translation. Biochimica et Biophysica Acta (BBA), 1852(16), 1178-1185. https://doi.org/10.1016/j.bbadis.2014.11.004
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The effect of resveratrol on live weight, serum biochemistry and tissue antioxidant enzymes in rats

Year 2023, Volume: 8 Issue: 2, 112 - 120, 30.08.2023
https://doi.org/10.31797/vetbio.1293543

Abstract

The aim of this study is to determine the effects of resveratrol used in adding it to drinking water. The study was carried out with 24 Wistar albino male 20 days rats for 40 days. The study design was determined as one control and two trial groups (each group with 2 parallels and each parallel with 4 rats). The first group was given a basal ration and drinking water. The second group was given the basal ration and drinking water with 10 mg/kg resveratrol; and the third group was given the basal ration and drinking water 20 mg/kg resveratrol. In serum biochemistry parameters, significant decreases were observed in serum Aspartate aminotransferase (AST) enzyme activity, blood urea nitrogen (BUN), albumin, total protein and globulin concentrations and increase in albumin/globulin ratio in groups given resveratrol (p<0.05). Regardless of the dose, an increase in the concentration of glutathione (GSH) from the antioxidant parameters was observed in the liver; In the kidney, an increase was observed in the Res10 group. In addition, a decrease in muscle superoxide dismutase (SOD) activity and an increase in muscle and kidney catalase (CAT) activity were observed. A decrease was observed in malondialdehyde (MDA) concentrations, which is a parameter of lipid peroxidation in the kidney. As a result, it was determined in the present study that resveratrol has antioxidant effects regardless of the way of use, and it was concluded that this additive can be used for various purposes.

References

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  • Badgujar, P.C., Pawar, N.N., Chandratre, G.A., Telang, A.G., Sharma, A.K. (2015). Fipronil induced oxidative stress in kidney and brain of mice: protective effect of vitamin E and vitamin C. Pesticide Biochemistry and Physiology, 118, 10-18. https://doi.org/10.1016/j.pestbp.2014.10.013
  • Baxter, R.A. (2008). Anti-aging properties of resveratrol: Review and report of a potent new antioxidant skin care formulation. Journal of Cosmetic Dermatology, 7, 2–7.
  • Bhatt, J.K., Thomas, S., Nanjan, M.J. (2012). Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus. Nutrition Research, 32(7), 537-541. https://doi.org/10.1016/j.nutres.2012.06.003
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  • Chand, N., Naz, S., Rehman, Z., Khan, R.U. (2018). Blood biochemical profile of four fast-growing broiler strains under high ambient temperature. Applied Biological Chemistry, 61(3), 273-279. https://doi.org/10.1007/s13765-018-0358-4
  • Comba, B., Cinar, A., Comba, A., Gencer, Y.G. (2016). Effects of ACTH application on kidney function tests, the electrolytes and hematological parameters in rats. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 63(3), 229-233.
  • Dal-Pan, A., Blanc, S., Aujard, F. (2010). Resveratrol suppresses body mass gain in a seasonal non-human primate model of obesity. BMC Physiology, 10(11). https://doi.org/10.1186/1472-6793-10-11
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  • Ghasemi, H.A., Nari, N. (2020). Effect of supplementary betaine on growth performance, blood biochemical profile, and immune response in heat-stressed broilers fed different dietary protein levels. Journal of Applied Poultry Research, 29(2), 301-313. https://doi.org/10.1016/j.japr.2019.11.004
  • Harada, N., Zhao, J., Kurihara, H., Nakagata, N., Okajima, K. (2011). Resveratrol improves cognitivefunction in mice by increasing production of insulin-like growth factor-I in the hippocampus. Journal of Nutritional Biochemistry, 22(12), 1150-1159. https://doi.org/10.1016/j.jnutbio.2010.09.016 Hausenblas, H.A., Schoulda, J.A., Smoliga, J.M., Schoulda, S. (2014). Resveratrol treatment as an adjunct to pharmacological management in type 2 diabetes mellitus-systematic review and meta-analysis. Molecular Nutrition and Food Research, 59(1), 147-159. https://doi.org/10.1002/mnfr.201400173 He, S., Li, S., Arowolo, M.A., Yu, Q., Chen, F., Hu, R., He, J. (2019). Effect of resveratrol on growth performance; rectal temperature and serum parameters of yellow‐feather broilers under heat stress. Animal Science Journal, 90(3), 401-411. https://doi.org/10.1111/asj.13161
  • Helkin, A., Stein, J.J., Lin, S., Siddiqui, S., Maier, K.G., Gahtan, V. (2016). Dyslipidemia part 1-review of lipid metabolism and vascular cell physiology. Vascular and Endovascular Surgery, 50(2), 107-118. https://doi.org/10.1177/1538574416628654
  • Hong, H.J., Kang, W., Kim, D.G., Lee, D.H., Lee, Y., Han, C. (2014). Effects of resveratrol on the insulin signaling pathway of obese mice. Journal of Veterinary Science, 15(2), 179-185. https://doi.org/10.4142/jvs.2014.15.2.179
  • Hu, H., Bai, X., Xu, K., Zhang, C., Chen, L. (2021). Effect of phloretin on growth performance, serum biochemical parameters and antioxidant profile in heat-stressed broilers. Poultry Science 100(8), 101217. https://doi.org/10.1016/j.psj.2021.101217
  • Jiang, Z., Wan, Y., Li, P., Xue, Y., Cui, W., Chen, Q., Mao, D. (2019). Effect of curcumin supplement in summer diet on blood metabolites, antioxidant status, immune response, and testicular gene expression in Hu sheep. Animals, 9(10), 720. https://doi.org/10.3390/ani9100720
  • Joe, A.K., Liu, H., Suzui, M., Vural, M.E., Xiao, D., Weinstein, I.B. (2002). Resveratrol induces growth inhibition, S-phase arrest, apoptosis, and changes in biomarker expression in several human cancer cell lines. Clinical Cancer Research, 8(3), 893–903.
  • Juan, M.E., Vinardell, M.P., Planas, J.M. (2002). The daily oral administration of high doses of trans-resveratrol to rats for 28 days is not harmful. Journal of Nutrition, 132, 257-260. https://doi.org/10.1093/jn/132.2.257
  • Khan, M.A., Chen, H.C., Wan, X.X., Tania, M., Xu, A.H., Chen, F.Z., Zhang, D.Z. (2013). Regulatory effects of resveratrol on antioxidant enzymes: A mechanism of growth inhibition and apoptosis induction in cancer cells. Molecular Cell, 35(3), 219-225. https://doi.org/10.1007/s10059-013-2259-z
  • Lee, E.S., Shin, M.O., Yoon, S., Moon, J.O. (2010). Resveratrol inhibits dimethylnitrosamine-induced hepatic fibrosis in rats. Archives of Pharmacal Research, 33, 925-932. https://doi.org/10.1007/s12272-010-0616-4
  • Liu, G.S., Zhang, Z.S., Yang, B., He, W. (2012). Resveratrol attenuates oxidative damage and ameliorates cognitive impairment in the brain of senescence-accelerated mice. Life Science, 91(17-18), 872–877. https://doi.org/10.1016/j.lfs.2012.08.033
  • Liu, L.L., He, J.H., Xie, H.B., Yang, Y.S., Li, J.C., Zou, Y. (2014). Resveratrol induces antioxidant and heat shock protein mRNA expression in response to heat stress in black-boned chickens. Poultry Science, 93(1), 54-62. https://doi.org/10.3382/ps.2013-03423
  • Moreno, M., Castro, E., Falqué, E. (2008). Evolution of trans- and cis- resveratrol content in red grapes (Vitis vinifera L. cv Menciá; Albarello and Merenzao) during ripening. European Food Research and Technology, 227(3), 667-674. https://doi.org/10.1007/s00217-007-0770-1
  • Mossa, A.T.H., Swelam, E.S., Mohafrash, S.M. (2015). Sub-chronic exposure to fipronil induced oxidative stress, biochemical and histopathological changes in the liver and kidney of male albino rats. Toxicology Reports, 2, 775-784. https://doi.org/10.1016/j.toxrep.2015.02.009
  • Nigdikar, S.V., Williams, N.R., Griffin, B.A., Howard, A.N. (1998). Consumption of red wine polyphenols reduces the susceptibility of low-density lipoproteins to oxidation in vivo. American Journal of Clinical Nutrition, 68(2), 258-265. https://doi.org/10.1093/ajcn/68.2.258
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  • OECD (Organization for Economic Cooperation and Development). (1995). Guidelines for testing chemicals. Repeated dose 28-d oral toxicity study in rodents, No. 407. Paris, France.
  • Ölmez, M., Şahin, T., Makav, M., Karadağoğlu, Ö. (2020). Effect of resveratrol supplemented to japanese quail (Coturnix coturnix japonica) rations on performance and some biochemical parameters. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 26(6), 807-812. https://doi.org/10.9775/kvfd.2020.24542
  • Pallauf, K., Chin, D., Gunther, I., Birringer, M., Luersen, K., Schultheiss, G., Vieten, S., Krauss, J., Bracher, F., Danylec, N., Soukop, S.T., Kulling, S.E., Rimbach, G. (2019). Resveratrol, lunularin and dihydroresveratrol do not act as caloric restriction mimetics when administered intraperitoneally in mice. Scientific Reports, 9(1), 4445. https://doi.org/10.1038/s41598-019-41050-2
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  • Rasković, A., Ćućuz, V., Torović, L., Tomas, A., Gojković-Bukarica, L., Ćebović, T., Milijašević, B., Stilinović, N., Cvejić Hogervorst, J. (2019). Resveratrol supplementation improves metabolic control in rats with induced hyperlipidemia and type 2 diabetes. Saudi Pharmaceutical Journal, 27(7), 1036–1043. https://doi.org/10.1016/j.jsps.2019.08.006
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There are 49 citations in total.

Details

Primary Language English
Subjects Veterinary Surgery
Journal Section Research Articles
Authors

Abdullah Özbilgin 0000-0002-1675-3176

Recep Gümüş 0000-0002-8812-191X

Mehmet Ekici 0000-0002-2163-6214

Nazlı Ercan 0000-0003-3542-3743

Early Pub Date August 29, 2023
Publication Date August 30, 2023
Submission Date May 6, 2023
Acceptance Date July 14, 2023
Published in Issue Year 2023 Volume: 8 Issue: 2

Cite

APA Özbilgin, A., Gümüş, R., Ekici, M., Ercan, N. (2023). The effect of resveratrol on live weight, serum biochemistry and tissue antioxidant enzymes in rats. Journal of Advances in VetBio Science and Techniques, 8(2), 112-120. https://doi.org/10.31797/vetbio.1293543

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