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Köpeklerde sevofloran ile oluşturulan inhalasyon anestezi öncesinde ksilazin-ketamin ya da propofol kullanımının postoperatif ağrı üzerine etkinliklerinin karşılaştırılması

Year 2018, Volume: 3 Issue: 1, 43 - 54, 30.06.2018
https://doi.org/10.24880/maeuvfd.401245

Abstract

Bu
çalışmada sevofloran gaz anestezisi için ksilazin-ketamin kombinasyonu veya
propofol ile sağlanan indüksiyonların postoperatif analjezi üzerine etkilerinin
karşılaştırılması amaçlandı. Hayvan materyalini ekstremite kırığı ile
kliniklerimize getirilen 14 adet köpek oluşturdu.  Köpekler 7’şerli iki gruba ayrıldı. Birinci
grupta indüksiyon amacıyla ksilazin HCl (1 mg/kg, iv) – ketamin HCl (2.5 mg/kg,
iv) kombinasyonu, ikinci grupta ise propofol (6 mg/kg, iv) kullanıldı. Her iki
grupta da indüksiyonu takiben köpekler entübe edilerek anestezinin devamı
sevofloran ile sürdürüldü. Operasyon öncesinde ve 5, 15, 30, 60. ve 90.
dakikalarında köpeklerin; vücut sıcaklıkları, solunum sayıları, kalp atım
sayıları ve oksijen saturasyonları kaydedildi. Ayrıca kan serumunda glikoz,
AST, ALT, BUN ve kreatinin değerleri belirlendi. Operasyondan sonra 2, 4, 6, 8,
12 ve 24. saatlerde kalp atım sayısı, solunum sayısı ve vücut sıcaklıkları
kaydedildi. Postoperatif aynı saatlerde basit ağrı tanımlama skalası (BAS),
Melbourne ağrı skalası (MAS) ve Glaskow kompozit ağrı skalasına (GKAS) göre
değerlendirme yapılarak gruplar ağrı bakımından karşılaştırıldı. Postoperatif 4.
saatte kalp atım sayıları grup içinde istatistiksel olarak farklı bulunmasına
rağmen gruplar arasında benzerdi. BAS, MAS ve GKAS’na göre I. Grupta postoperatif
6, II. grupta postoperatif 4. saatte istatistiksel olarak anlamlı bir fark
belirlendi. Sonuç olarak ketaminin analjezik etkisinin operasyon sonrası
dönemde propofole kıyasla daha uzun süre devem ettiği görüldü.

References

  • 1. Güzel Ö, Yıldar E, Karabağlı M, Erdikmen DO, Ekici A. Comparison of the Effects of Spontaneous and Mechanical Ventilation on Blood Gases During General Anaesthesia in Dogs. Kafkas Univ Vet Fak Derg. 2013; 19 (Supl-A): A19-A25.
  • 2. Willman EV, Andolfatto G. A prospective evaluation of “ketofol” (ketamine/propofol combination) for procedural sedation and analgesia in the emergency department. Annals of Emergency Medicine. 2007; 49 (1): 23-30.
  • 3. Gültekin Ç. Tümör cerrahisi uygulanan köpeklerde morfin ve tramadol’ün analjezik etkilerinin karşılaştırılması. Doktora Tezi, Ankara Üniversitesi Sağlık Bilimleri Enstitüsü, 2012.
  • 4. Kuzucu O. Köpeklerde karprofen ve fluniksin’in postoperatif analjezik etkinliklerinin karşılaştırılması. Doktora tezi, Ankara Üniversitesi Sağlık Bilimleri Enstitüsü, Ankara, 2005.
  • 5. Hellyer P, Rodan I, Burnt J, Downing R, Hagedorn JE, Robertson SA. AAHA/AAFP pain management guidelines for dogs and cats. J Feline Med Surg. 2007; 9:466–480.
  • 6. Flecknell PA. Advances in the assessment and alleviation of pain in laboratory and domestic animals. J Vet Anesth. 1994; 21: 98-105.
  • 7. Fitzpatrick CL, Weir HL, Monnet E. Effects of infiltration of the incision site with bupivacaine on postoperative pain and incisional healing in dogs undergoing ovariohysterectomy. JAVMA. 2010; 237 (4), 395-401.
  • 8. Guerrero KSK, Campagna I, Bruhl-Day R, Hegamin-Younger C. Intraperitoneal bupivacaine with or without incisional bupivacaine for postoperative analgesia in dogs undergoing ovariohysterectomy. Vet Anaest Analg. 2016; 43, 571–578.
  • 9. Mich PM, Hellyer PW. Objective, categoric methods for assessing pain and analgesia, In: Handbook of Veterinary Pain Management, Ed; Gaynor JS, Muir III, 2nd. ed WW. Missouri: Mosby, 2009pp. 78-109.
  • 10. Saritas ZK, Korkmaz M, Yilmaz O. The effect of intravenously given dexketoprofen trometamol on postoperative pain in ovariohysterectomized dogs. Eurasian J Vet Sci. 2014; 30, 5-10.
  • 11. Campagnol D, Teixeira-Neto FJ, Monteiro EM, Restitutti F, Minto BW. Effect of intraperitoneal or incisional bupivacaine on pain and the analgesic requirement after ovariohysterectomy in dogs. Vet Anaest Analg. 2012; 39, 426–430.
  • 12. Savas I, Papazoğlu LG, Kazakos G, Anagnostou T, Tsioli V, Raptopoulos D. Incisional block with bupivacaine for analgesia after celiotomy in dogs. J Am Anim Hosp Assoc.2008; 44: 60–66.
  • 13. Schuszler L, Igna C, Sala A, Brudiu I, Sabau M, Dascalu R. Intraoperative analgesic effect of butarphanol for ovariohysterectomy in bitches: a dose titration study. Lucrari Ştiintifice Med Vet. 2009; 2, 160-163.
  • 14. Benito J, Monteiro BP, Beaudry F, Lavoie AM, Lascelles BDX, Steagall PV. Harmacokinetics of bupivacaine after intraperitoneal administration to cats undergoing ovariohysterectomy. AJVR. 2016; 77 (6), 641-645.
  • 15. Akın A, Güler G, Esmaoğlu A, Bedirli N, Boyacı A. A comparison of fentanylpropofol with a ketamine-propofol combination for sedation during endometrial biopsy. J Clin Anesth. 2005;17:187-190.
  • 16. Guit JBM, Koning HM, Coster ML, Nıemeıjer RPE, Mackı DP. Ketamine as analgesic for total intravenous anastehesia with propofol. Anaesthesia. 1991; 46: 24-27.
  • 17. Hui TW, Short TG, Hong W, Suen T, Gin T, Plummer J. Additive interactions between propofol and ketamine when used for anaeshesia induction in female patients. Anesthesiology. 1995; 82: 641-648.
  • 18. Mortero RF, Clark LD, Tolan MM, Metz RJ, Tsueda K, Sheppard RA. The Effects of Small-Dose Ketamine on Propofol Sedation: Respiration, Postoperative Mood, Perception, Cognition and Pain. Anesth Analg. 2001; 92: 1465-9.
  • 19. Yayla S, Kaçar C, Kaya D, Merhan O, Aksoy Ö, Kılıç E, Kaya S. Clinical, Biocheical and haemodynamic effects of the intrathecal ketamine for ovariohysterectomy in bitches. Bull Vet Inst Pulawy. 2012; 56: 299-303.
  • 20. Topal A. Enjektable Anestezikler, In: Veteriner Anestezi, 1. Baskı., Nobel Tıp Kitapevleri Ltd. Şti, İstanbul, Türkiye. 2005; pp. 112-128.
  • 21. Yayla S, Kaçar C, Kılıç E, Kaya S, Kuru M, Ermutlu CŞ, Özaydın İ, Hüseyinoğlu Ü, Öğün M. The Effects of Intrathecal Administration of Bupivacaine or Ropivacaine Following Administration of Propofol in Dogs Undergoing Ovariohysterectomy. Kafkas Univ Vet Fak Derg. 2017, 23(3):363-367.
  • 22. Özyılmaz MA, Ölmez G, Şimşek E. Laparoskopik kolesistektomilerde genel anestezik altında preemptif ketamine ile intraperitoneal ropivakain kombinasyonunun postoperatif analjezik etkilerinin karşılaştırılması. Fırat Tıp Dergisi. 2006; 11 (2): 116-120.
  • 23. Kim YK, Lee SS, Suh EH, Lee L, Lee HC, Lee HJ, Yeon SC. Sprayed intraperitoneal bupivacaine reduces early postoperative pain behavior and biochemical stress response after laparoscopic ovariohysterectomy in dogs. Vet J. 2012; 191: 188–192.
  • 24. Albanese J, Arnaud S, Rey M,Thomachot L, Alliez B, Martin C. Ketamine decreases intracranial pressure and electroencephalographic activity in traumatic brain injury patients during propofol sedation. Anesthesiology. 1997; 87: 1328-34.
  • 25. Kılıç E, Yayla S, Kamiloğlu A, Baran V, Öğün M. Effects of intrathecal administration of ketamine HCl in young calves: a clinical trial. Bull Vet Inst Pulawy. 2015; 59: 155-159.

Comparison of effect on postoperative pain of use of xylazine-ketamine or propofol prior to sevoflurane-induced inhalation anesthesia in dogs

Year 2018, Volume: 3 Issue: 1, 43 - 54, 30.06.2018
https://doi.org/10.24880/maeuvfd.401245

Abstract

In this study, it was aimed to
compare the effects on postoperative analgesia of xylazine-ketamine combination
or propofol to induction for sevoflurane gas anesthesia. The animal material
consisted of 14 dogs with limb fracture brought to our clinics. The dogs were
divided into two groups of seven. For induction, it was used combination of
xylazine HCl (1 mg / kg, iv) - ketamine HCl (2.5 mg / kg, iv) in the first
group and propofol (6 mg / kg iv) in the second group. In both groups, dogs
were intubated and the anesthesia continued with sevoflurane followed by
induction.
At the beginning of the operation and at 5, 15, 30, 60, and 90 minutes,
body temperatures, respiratory counts, heart rate counts, and oxygen saturates
were recorded. Glucose, AST, ALT, BUN and creatinine values were also
determined in the blood serum. Heart rate, respiratory rate and body
temperature were recorded at 2, 4, 6, 8, 12 and 24 hours after the operation.
At the same time postoperatively, the groups were compared according to simple pain
definition scale, Melbourne pain scale and Glaskow composite pain scale. Heart
rates at postoperative 4th hour were statistically different in the group but
similar between the groups.
According to simple pain definition scale, Melbourne
pain scale and Glaskow composite pain scale, there was a statistically
significant difference at postoperative 6th hour in the group I and
postoperative 4th hour in the Group II. As a result, it was observed that the
analgesic effect of ketamine was longer in the postoperative period compared to
propofol.

References

  • 1. Güzel Ö, Yıldar E, Karabağlı M, Erdikmen DO, Ekici A. Comparison of the Effects of Spontaneous and Mechanical Ventilation on Blood Gases During General Anaesthesia in Dogs. Kafkas Univ Vet Fak Derg. 2013; 19 (Supl-A): A19-A25.
  • 2. Willman EV, Andolfatto G. A prospective evaluation of “ketofol” (ketamine/propofol combination) for procedural sedation and analgesia in the emergency department. Annals of Emergency Medicine. 2007; 49 (1): 23-30.
  • 3. Gültekin Ç. Tümör cerrahisi uygulanan köpeklerde morfin ve tramadol’ün analjezik etkilerinin karşılaştırılması. Doktora Tezi, Ankara Üniversitesi Sağlık Bilimleri Enstitüsü, 2012.
  • 4. Kuzucu O. Köpeklerde karprofen ve fluniksin’in postoperatif analjezik etkinliklerinin karşılaştırılması. Doktora tezi, Ankara Üniversitesi Sağlık Bilimleri Enstitüsü, Ankara, 2005.
  • 5. Hellyer P, Rodan I, Burnt J, Downing R, Hagedorn JE, Robertson SA. AAHA/AAFP pain management guidelines for dogs and cats. J Feline Med Surg. 2007; 9:466–480.
  • 6. Flecknell PA. Advances in the assessment and alleviation of pain in laboratory and domestic animals. J Vet Anesth. 1994; 21: 98-105.
  • 7. Fitzpatrick CL, Weir HL, Monnet E. Effects of infiltration of the incision site with bupivacaine on postoperative pain and incisional healing in dogs undergoing ovariohysterectomy. JAVMA. 2010; 237 (4), 395-401.
  • 8. Guerrero KSK, Campagna I, Bruhl-Day R, Hegamin-Younger C. Intraperitoneal bupivacaine with or without incisional bupivacaine for postoperative analgesia in dogs undergoing ovariohysterectomy. Vet Anaest Analg. 2016; 43, 571–578.
  • 9. Mich PM, Hellyer PW. Objective, categoric methods for assessing pain and analgesia, In: Handbook of Veterinary Pain Management, Ed; Gaynor JS, Muir III, 2nd. ed WW. Missouri: Mosby, 2009pp. 78-109.
  • 10. Saritas ZK, Korkmaz M, Yilmaz O. The effect of intravenously given dexketoprofen trometamol on postoperative pain in ovariohysterectomized dogs. Eurasian J Vet Sci. 2014; 30, 5-10.
  • 11. Campagnol D, Teixeira-Neto FJ, Monteiro EM, Restitutti F, Minto BW. Effect of intraperitoneal or incisional bupivacaine on pain and the analgesic requirement after ovariohysterectomy in dogs. Vet Anaest Analg. 2012; 39, 426–430.
  • 12. Savas I, Papazoğlu LG, Kazakos G, Anagnostou T, Tsioli V, Raptopoulos D. Incisional block with bupivacaine for analgesia after celiotomy in dogs. J Am Anim Hosp Assoc.2008; 44: 60–66.
  • 13. Schuszler L, Igna C, Sala A, Brudiu I, Sabau M, Dascalu R. Intraoperative analgesic effect of butarphanol for ovariohysterectomy in bitches: a dose titration study. Lucrari Ştiintifice Med Vet. 2009; 2, 160-163.
  • 14. Benito J, Monteiro BP, Beaudry F, Lavoie AM, Lascelles BDX, Steagall PV. Harmacokinetics of bupivacaine after intraperitoneal administration to cats undergoing ovariohysterectomy. AJVR. 2016; 77 (6), 641-645.
  • 15. Akın A, Güler G, Esmaoğlu A, Bedirli N, Boyacı A. A comparison of fentanylpropofol with a ketamine-propofol combination for sedation during endometrial biopsy. J Clin Anesth. 2005;17:187-190.
  • 16. Guit JBM, Koning HM, Coster ML, Nıemeıjer RPE, Mackı DP. Ketamine as analgesic for total intravenous anastehesia with propofol. Anaesthesia. 1991; 46: 24-27.
  • 17. Hui TW, Short TG, Hong W, Suen T, Gin T, Plummer J. Additive interactions between propofol and ketamine when used for anaeshesia induction in female patients. Anesthesiology. 1995; 82: 641-648.
  • 18. Mortero RF, Clark LD, Tolan MM, Metz RJ, Tsueda K, Sheppard RA. The Effects of Small-Dose Ketamine on Propofol Sedation: Respiration, Postoperative Mood, Perception, Cognition and Pain. Anesth Analg. 2001; 92: 1465-9.
  • 19. Yayla S, Kaçar C, Kaya D, Merhan O, Aksoy Ö, Kılıç E, Kaya S. Clinical, Biocheical and haemodynamic effects of the intrathecal ketamine for ovariohysterectomy in bitches. Bull Vet Inst Pulawy. 2012; 56: 299-303.
  • 20. Topal A. Enjektable Anestezikler, In: Veteriner Anestezi, 1. Baskı., Nobel Tıp Kitapevleri Ltd. Şti, İstanbul, Türkiye. 2005; pp. 112-128.
  • 21. Yayla S, Kaçar C, Kılıç E, Kaya S, Kuru M, Ermutlu CŞ, Özaydın İ, Hüseyinoğlu Ü, Öğün M. The Effects of Intrathecal Administration of Bupivacaine or Ropivacaine Following Administration of Propofol in Dogs Undergoing Ovariohysterectomy. Kafkas Univ Vet Fak Derg. 2017, 23(3):363-367.
  • 22. Özyılmaz MA, Ölmez G, Şimşek E. Laparoskopik kolesistektomilerde genel anestezik altında preemptif ketamine ile intraperitoneal ropivakain kombinasyonunun postoperatif analjezik etkilerinin karşılaştırılması. Fırat Tıp Dergisi. 2006; 11 (2): 116-120.
  • 23. Kim YK, Lee SS, Suh EH, Lee L, Lee HC, Lee HJ, Yeon SC. Sprayed intraperitoneal bupivacaine reduces early postoperative pain behavior and biochemical stress response after laparoscopic ovariohysterectomy in dogs. Vet J. 2012; 191: 188–192.
  • 24. Albanese J, Arnaud S, Rey M,Thomachot L, Alliez B, Martin C. Ketamine decreases intracranial pressure and electroencephalographic activity in traumatic brain injury patients during propofol sedation. Anesthesiology. 1997; 87: 1328-34.
  • 25. Kılıç E, Yayla S, Kamiloğlu A, Baran V, Öğün M. Effects of intrathecal administration of ketamine HCl in young calves: a clinical trial. Bull Vet Inst Pulawy. 2015; 59: 155-159.
There are 25 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Research Articles
Authors

Celal Şahin Ermutlu

Publication Date June 30, 2018
Submission Date March 4, 2018
Published in Issue Year 2018 Volume: 3 Issue: 1

Cite

APA Ermutlu, C. Ş. (2018). Köpeklerde sevofloran ile oluşturulan inhalasyon anestezi öncesinde ksilazin-ketamin ya da propofol kullanımının postoperatif ağrı üzerine etkinliklerinin karşılaştırılması. Veterinary Journal of Mehmet Akif Ersoy University, 3(1), 43-54. https://doi.org/10.24880/maeuvfd.401245