Abstract
Bu çalışmada 20 günlük bir süt kuzusunda pulmoner aspergillozis vakası tanımlanmıştır. Yüksek ateş, iştahsızlık, halsizlik ve denge problemleri yaşayan kuzu nekropsisi yapılmak üzere Kafkas Üniversitesi Veteriner Fakültesi Patoloji Anabilim Dalı’na getirildi. Hayvan sahibinden alınan anamnez bilgilerine göre hayvana yoğun ve gelişigüzel bir şekilde ilaç tedavisi yapıldığı kaydedildi. Ardından hayvanın sistemik nekropsisi yapıldı. Histopatolojik ve mikrobiyolojik incelemeler için hayvandan çeşitli doku örnekleri alındı. Makroskobik muayenede hayvanın akciğerinde sadece bir alanda 2*2 mm çapında sarımtırak beyaz renkli bir odak tespit edildi. Histopatolojik incelemelerde, akciğerde granulom yapısı saptandı. Bu granulomun merkezinde ise şiddetli nekrozun yanı sıra nötrofiller ve mantar hifalarının varlığı tespit edildi. Akciğer dokusunun PAS boyamasında bu hifaların pozitif reaksiyon verdiği ve boya aldığı kaydedildi. Akciğer ve karaciğer dokularının Ziehl-Neelsen boyamalarında bu dokuların tüberküloz yönünden negatif olduğu tespit edildi. Histopatolojik ve mikrobiyolojik incelemeler sonucunda süt kuzularında oldukça nadir olarak görülen bu vakaya pulmoner aspergillozis tanısı konuldu.
References
- Referans1Amchentsev A, Kurugundla N, Saleh A (2008). Aspergillus-related lung disease. Respir Med CME 1: 205-215. https://doi.org/10.1016/j.rmedc.2008.08.008
- Referans2Aslan Ö, Yaman D, Karaca Bekdik İ, Abay S, Ekebaş G (2015) Bir güvercin sürüsünde Aspergillus fumigatus enfeksiyonu. Erciyes Üniv Vet Fak Derg 12:147-152.
- Referans3Austwick PKC, Gitter M, Watkins CV (1960) Pulmonary aspergillosis in lambs. Vet Rec 72: 19-20.
- Referans4Cafarchia C, Paradies R, Figueredo LA, Padalino B, Greco MF, Greco G, Otranto D (2012) A case of equine aspergillosis: a novel sampling procedure for diagnosis. JEVS 32:634-637. https://doi.org/10.1016/j.jevs.2012.02.009
- Referans5Chihaya Y, Matsukawa K, Takahashi K, Matsui Y, Koosaka Y, Niioka K, Mizushima S (1980) An ovine case of generalized aspergillosis with alimentary lesions. Nihon Juigaku Zasshi 42:703-707. https://doi.org/10.1292/jvms1939.42.703
- Referans6Dagleish MP, Benavides J, Chianini F (2010) Immunohistochemical diagnosis of infectious diseases of sheep. Small Ruminant Res 92:19–35. https://doi.org/10.1016/j.smallrumres.2010.04.003
- Referans7do Carmo PM, Portela RA, de Oliveira-Filho JC, Dantas AF, Simões SV, Garino F Jr, Riet-Correa F (2014) Nasal and cutaneous aspergillosis in a goat. J Comp Pathol 150:4-7. https://doi.org/10.1016/j.jcpa.2013.06.007
- Referans8Fragner P, Vítovec J, Vladík P, Tesařík L (1970) Bronchopulmonary aspergillosis in lamb. Mycopathol Mycol Appl 40:337-340.
- Referans9Gracey JF, Baxter JT (1961) Generalized Aspergillus fumigaus infection in a lamb. Br Vet J 117:11-14.
- Referans10Latif H, Gross M, Fischer D, Lierz M, Usleber E (2015) Immunochemical analysis of fumigaclavine mycotoxins in respiratory tissues and in blood serum of birds with confirmed aspergillosis. Mycotoxin Res 31:177-183. https://doi.org/10.1007/s12550-015-0228-4
- Referans11Ohshima K, Miura S, Seimiya Y, Chihaya Y (1976) Pathological studies on mucormycosis of the forestomach and abomasum in ruminants: a report on six cases complicated with candidiasis or pulmonary aspergillosis. Nihon Juigaku Zasshi 38:269-280. https://doi.org/10.1292/jvms1939.38.269
- Referans12Pérez V, Corpa JM, García Marín JF, Adúriz JJ, Jensen HE (1998) Mammary and systemic aspergillosis in dairy sheep. Vet Pathol 35:235-240. https://doi.org/10.1177/030098589803500401
- Referans13Pérez V, Corpa JM, Garćia Marín JF, Adúriz JJ, Jensen HE (1999) Generalized aspergillosis in dairy sheep. Zentralbl Veterinarmed B 46:613-621. https://doi.org/10.1046/j.1439-0450.1999.00290.x
- Referans14Savelieff MG, Pappalardo L, Azmanis P (2018) The current status of avian aspergillosis diagnoses: Veterinary practice to novel research avenues. Vet Clin Pathol 47:342-362. https://doi.org/10.1111/vcp.12644
- Referans15Seyedmousavi S, Bosco SMG, de Hoog S, Ebel F, Elad D, Gomes RR, Jacobsen ID, Jensen HE, Martel A, Mignon B, Pasmans F, Piecková E, Rodrigues AM, Singh K, Vicente VA, Wibbelt G, Wiederhold NP, Guillot J (2018) Fungal infections in animals: a patchwork of different situations. Med Mycol 56:165-187. https://doi.org/10.1093/mmy/myx104
- Referans16Seyedmousavi S, Guillot J, Arné P, de Hoog GS, Mouton JW, Melchers WJ, Verweij PE (2015) Aspergillus and aspergilloses in wild and domestic animals: a global health concern with parallels to human disease. Med Mycol 53:765-797. https://doi.org/10.1093/mmy/myv067
- Referans17Swatek R, Halde C, Rinaldi MJ, Shadomy HJ (1985) Aspergillus species and other opportunistic saprophytic hyaline Hyphomycetes. In: Lennette EH, Balows A, Hausler Jr WJ, Shadomy HJ (Eds) Manual of Clinical Microbiology, 4th edn. American Society for Microbiology, ASM Press, Washington, pp 584–594.
- Referans18Şahin M, Aydın F, Genç O, Güler MA (1997) Kazlardan Aspergillus fumigatus izolasyonu ve identifikasyonu. Kafkas Üniv Vet Fak Derg 3:19-23.
- Referans19Tell LA (2005). Aspergillosis in mammals and birds: impact on veterinary medicine. Med Mycol 43:S71-73. https://doi.org/10.1080/13693780400020089
- Referans20Young NE (1970) Pulmonary aspergillosis in the lamb. Vet Rec 86:790. https://doi.org/10.1136/vr.86.26.790
Abstract
In this study, a case of pulmonary aspergillosis was described in a 20-day-old suckling lamb. Lamb suffering from high fever, anorexia, weakness and balance disorder was brought to the Department of Pathology of Kafkas University Faculty of Veterinary Medicine for necropsy. According to the anamnesis obtained from the animal owner, an intense and random drug treatment was administered to the animal. Following the systemic necropsy of the animal, various tissue samples were taken from for histopathological and microbiological analysis. On macroscopic examination, a yellowish-white colored focus in a diameter of 2x2 mm was detected in only one area of the animal's lung. Histopathological examinations revealed a granuloma in the lung. In the center of this granuloma, in addition to severe necrosis, neutrophils and fungal hyphae were detected. In the PAS staining of the lung tissue, it was noted that these hyphae took the stain and gave a positive reaction in terms of fungus. Ziehl-Neelsen staining of the lung and liver tissues revealed that these tissues were negative for tuberculosis. As a result of histopathological and microbiological analysis, this case, which is rarely seen in dairy lambs, was diagnosed as pulmonary aspergillosis.
References
- Referans1Amchentsev A, Kurugundla N, Saleh A (2008). Aspergillus-related lung disease. Respir Med CME 1: 205-215. https://doi.org/10.1016/j.rmedc.2008.08.008
- Referans2Aslan Ö, Yaman D, Karaca Bekdik İ, Abay S, Ekebaş G (2015) Bir güvercin sürüsünde Aspergillus fumigatus enfeksiyonu. Erciyes Üniv Vet Fak Derg 12:147-152.
- Referans3Austwick PKC, Gitter M, Watkins CV (1960) Pulmonary aspergillosis in lambs. Vet Rec 72: 19-20.
- Referans4Cafarchia C, Paradies R, Figueredo LA, Padalino B, Greco MF, Greco G, Otranto D (2012) A case of equine aspergillosis: a novel sampling procedure for diagnosis. JEVS 32:634-637. https://doi.org/10.1016/j.jevs.2012.02.009
- Referans5Chihaya Y, Matsukawa K, Takahashi K, Matsui Y, Koosaka Y, Niioka K, Mizushima S (1980) An ovine case of generalized aspergillosis with alimentary lesions. Nihon Juigaku Zasshi 42:703-707. https://doi.org/10.1292/jvms1939.42.703
- Referans6Dagleish MP, Benavides J, Chianini F (2010) Immunohistochemical diagnosis of infectious diseases of sheep. Small Ruminant Res 92:19–35. https://doi.org/10.1016/j.smallrumres.2010.04.003
- Referans7do Carmo PM, Portela RA, de Oliveira-Filho JC, Dantas AF, Simões SV, Garino F Jr, Riet-Correa F (2014) Nasal and cutaneous aspergillosis in a goat. J Comp Pathol 150:4-7. https://doi.org/10.1016/j.jcpa.2013.06.007
- Referans8Fragner P, Vítovec J, Vladík P, Tesařík L (1970) Bronchopulmonary aspergillosis in lamb. Mycopathol Mycol Appl 40:337-340.
- Referans9Gracey JF, Baxter JT (1961) Generalized Aspergillus fumigaus infection in a lamb. Br Vet J 117:11-14.
- Referans10Latif H, Gross M, Fischer D, Lierz M, Usleber E (2015) Immunochemical analysis of fumigaclavine mycotoxins in respiratory tissues and in blood serum of birds with confirmed aspergillosis. Mycotoxin Res 31:177-183. https://doi.org/10.1007/s12550-015-0228-4
- Referans11Ohshima K, Miura S, Seimiya Y, Chihaya Y (1976) Pathological studies on mucormycosis of the forestomach and abomasum in ruminants: a report on six cases complicated with candidiasis or pulmonary aspergillosis. Nihon Juigaku Zasshi 38:269-280. https://doi.org/10.1292/jvms1939.38.269
- Referans12Pérez V, Corpa JM, García Marín JF, Adúriz JJ, Jensen HE (1998) Mammary and systemic aspergillosis in dairy sheep. Vet Pathol 35:235-240. https://doi.org/10.1177/030098589803500401
- Referans13Pérez V, Corpa JM, Garćia Marín JF, Adúriz JJ, Jensen HE (1999) Generalized aspergillosis in dairy sheep. Zentralbl Veterinarmed B 46:613-621. https://doi.org/10.1046/j.1439-0450.1999.00290.x
- Referans14Savelieff MG, Pappalardo L, Azmanis P (2018) The current status of avian aspergillosis diagnoses: Veterinary practice to novel research avenues. Vet Clin Pathol 47:342-362. https://doi.org/10.1111/vcp.12644
- Referans15Seyedmousavi S, Bosco SMG, de Hoog S, Ebel F, Elad D, Gomes RR, Jacobsen ID, Jensen HE, Martel A, Mignon B, Pasmans F, Piecková E, Rodrigues AM, Singh K, Vicente VA, Wibbelt G, Wiederhold NP, Guillot J (2018) Fungal infections in animals: a patchwork of different situations. Med Mycol 56:165-187. https://doi.org/10.1093/mmy/myx104
- Referans16Seyedmousavi S, Guillot J, Arné P, de Hoog GS, Mouton JW, Melchers WJ, Verweij PE (2015) Aspergillus and aspergilloses in wild and domestic animals: a global health concern with parallels to human disease. Med Mycol 53:765-797. https://doi.org/10.1093/mmy/myv067
- Referans17Swatek R, Halde C, Rinaldi MJ, Shadomy HJ (1985) Aspergillus species and other opportunistic saprophytic hyaline Hyphomycetes. In: Lennette EH, Balows A, Hausler Jr WJ, Shadomy HJ (Eds) Manual of Clinical Microbiology, 4th edn. American Society for Microbiology, ASM Press, Washington, pp 584–594.
- Referans18Şahin M, Aydın F, Genç O, Güler MA (1997) Kazlardan Aspergillus fumigatus izolasyonu ve identifikasyonu. Kafkas Üniv Vet Fak Derg 3:19-23.
- Referans19Tell LA (2005). Aspergillosis in mammals and birds: impact on veterinary medicine. Med Mycol 43:S71-73. https://doi.org/10.1080/13693780400020089
- Referans20Young NE (1970) Pulmonary aspergillosis in the lamb. Vet Rec 86:790. https://doi.org/10.1136/vr.86.26.790
Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Surgery |
| Journal Section | Case Report |
| Authors | |
| Publication Date | September 3, 2021 |
| Published in Issue | Year 2021Volume: 3 Issue: 1 |
