Comparative Evaluation of Intramuscular, Intranasal, Oral and Intraosseal Administration of Midazolam, Ketamine Combination in Quail (Coturnix coturnix japonica)
Abstract
This study was aimed to compare the effects of
different delivery routes of midazolam ketamine combination in quails. Thirty
two adult male quails (Coturnix coturnix japonica) with a mean weight of
180-220 gr and a 25-week-old were used in this study. The birds were divided into four groups of
eight animals each. In group I (Group IM), 6 mg/kg midazolam-100 mg/kg ketamine
combination was injected intramuscularly. It was given the same dose of this
combination intranasal in the group II (Group IN) and orally in the group III
(Group O). In the last group (Group IO), 2 mg/kg midazolam-20 mg/kg ketamine
was administered intraosseally. Induction, recovery time and depth of
anesthesia were evaluated. Pulse, systolic blood pressure, diastolic blood
pressure, respiratory rate and cloacal temperature were also monitored. The
anesthesia durations were determined as 28.88±5.87 min in group IM, 13.75±5.18
min in group IN, 14.88±4.79 min in group O and 38.13±8.84 min in group IO,
respectively. There were statistically significant differences between groups
in terms of both anesthesia duration and physiological values. As a result,
intramuscular and oral administration of the midazolam ketamine combination may
be preferred to many operative interventions, but intranasal use can be used
for clinical examination or diagnostic procedures because it does not provide
adequate anesthesia. It can be said that oral and intraosseous use may be
preferred in cases requiring longer duration of anesthesia in birds.
Keywords
References
- 1. Maiti SK, Tiwary R, Vasan P, Dutta A. (2006). Xylazine, diaze-pam and midazolam premedicated ketamine anaesthesia in White Leghorn cockerels for typlectomy. S Afr Vet Ver, 77 (1): 12-18.
- 2. Mans C. (2014) Sedation of pet birds. Journal of Exotic Pet Medicine. 23, 152-157.
- 3. Durrani UF, Khan MA, Ahmad SS. (2008). Comparative efficacy (sedative and anesthetic) of detomidine, ketamine and detomidine-ketamine cocktail in peigeons (Culumbia livia). Pa-kistan Vet J. 28 (3): 115-118.
- 4. Durrani UF, Ashraf M, Khalid A. (2005). Comparative efficacy of detomidine and detomidine cocktail in quails. Pakistan Vet J. 25 (4): 197-199.
- 5. Durrani UF, Ashraf M, Khan MA. (2009). A comparison of the clinical effects associated with xylazine, ketamine and a xylazine-ketamine cocktail in pigeons (Columba livia). Turk J Vet Anim Sci. 33 (5): 413-417.
- 6. Kamiloglu A, Yayla S, Kamiloglu NN, Ozaydin I, Kurt B: Clinical evaluation of intramuscular and intraosseous xylazine-ketamine anesthesia in quails (Coturnix coturnix japonica). Erciyes Üniv Vet Fak Derg. 11(3): 169-174, 2014.
- 7. Yayla S, Kamiloglu N, Kamiloglu A, Ozaydin I: Comparision of intravenous and intraosseous administration of propofol-ketamine combination for anesthesia in quails (Coturnix coturnix japonica). Kocatepe Vet J. 7 (1): 11-16, 2014.
- 8. Yayla S, Kamiloglu NN, Kamiloglu A, Ozaydın I, Ermutlu CS. (2015). Comparison of the effects of intramuscular and in-traosseal administration of detomidine/ ketamine combina-tion for general anaesthesia in quails (Coturnix coturnix japon-ica). Bulg J Agric Sci. 21, 220-224.
- 9. Akgul MB, Sindak N, Gulaydin A, Ozen D. (2017). Clinical evaluation of xylazine-ketamine and medetomidine-ketamine anesthesia in japanese quails (Coturnix coturnix japonica). Erciyes Üniv Vet Fak Derg. 14 (3): 169-176.
- 10. Schaffer DPH, Araujo NNLJ, Raposa ACS, Filho AFM, Vieira JVR, Oria AP. (2017). Sedative effect of intranasal midazolam administration in wild caught blue-fronted amazon (Amozona aestiva) and orange-winged amazon (Amozona amazonica) parrots. J Avian Med Surg. 31(3): 213-218.
- 11. Day TK, Roge CK. (1996). Evaluation of sedation in quail in-duced by use of midazolam and reversed by use of flumazenil. J Am Vet Med Assoc. 209 (5): 969-971.
- 12. Sadegh AB. (2013). Comparison of intranasal administration of xylazine, diazepam, and midazolam in budgerigars (Melopsittacus undalatus): Clinical evaluation. J Zoo Wild Med. 44 (2): 241-244.
- 13. Moghadam AZ, Sadegh AB, Sharifi S, Habibian S. (2009). Comparison of intranasal administration of diazepem midazolam and xylazine in pigeons: Clinical evaluation. IJVST, 1 (1): 19-26.
- 14. Schaffer DPH, Raposa ACS, Liberiou FA, Silva RMM, Araujo NLLJ, Oria AP. (2016). Intranasal administration of midazolam in blue and yellow macaws (Ara araruana): Evaluation of sedative effects. Veterinary Anest Analg. 43, 459-460.
- 15. Kamiloglu A, Atalan G, Kamiloglu NN. (2007). Comparison of intraosseous and intramuscular drug administration for induc-tion of anesthesia in domestic pigeons. Res Vet Sci. 85, 171-175.
- 16. Guzman DSM. (2014). Advances in avian clinical therapeutics. Journal of Exotic Pet Medicine 23, 6-20.
- 17. Valverde AD, Bienzle D, Smith DA, Dyson DH, Valliant AE. (1993). Intraosseus cannulation and drug administration for induction of anesthesia in chickens. Vet Surg. 22, 240-244.
- 18. English MJ, Papenberg R, Farias E, Scott WAC, Hinchey J. (1991). Heat loss in an animal experimental model. J Trauma. 31, 36-38.
Bıldırcınlarda (Coturnix coturnix japonica) Midazolam-Ketamin Kombinasyonunun İntramusküler, İntranasal, Oral ve İntraosseal Olarak Uygulanmasının Karşılaştırmalı Olarak Değerlendirilmesi
Abstract
Bu çalışmada midazolam ketamin kombinasyonunun
farklı veriliş yollarının etkilerinin karşılaştırmalı olarak değerlendirilmesi
amaçlandı. Çalışmada toplam 32 adet erkek, ortalama 180-220 gr ağırlığında ve
25 haftalık erişkin bıldırcın (Coturnix coturnix japonica) kullanıldı. Kuşlar
her birinde 8 hayvan olacak şekilde dört gruba ayrıldı. Grup I’de (Grup IM) 6
mg/kg dozunda midazolam-100 mg/kg ketamin kombinasyonu intamusküler olarak
enjekte edildi. Grup II’de aynı dozdaki kombinasyon intranasal (Grup IN), III.
gruba ise oral (Grup O) olarak uygulandı. Son gruba da 2 mg/kg midazolam-20
mg/kg ketamin intraosseal (Grup IO) olarak uygulandı. Anesteziye giriş ve çıkış
süreleri ve anestezi derinliği değerlendirildi. Ayrıca nabız, sistolik ve
diastolik kan basınçları ile solunum sayısı ve kloakal ısı takip edildi.
Anestezi süreleri sırasıyla grup IM’de 28.88±5.87, grup IN’de 13.75±5.18, grup
O’da 14.88±4.79 ve grup IO’de 38.13±8.84 olarak belirlendi. Gruplar arasında
hem anestezi süreleri hem de fizyolojik değerler bakımından istatistiksel
olarak anlamlı farklılıklar bulundu. Sonuç olarak midazolam ketamin
kombinasyonun intramusküler ve oral kullanımı birçok operatif girişim için
tercih edilebilir, fakat intranasal kullanım yeterli derinlikte anestezi
sağlayamadığından dolayı sadece klinik muayene ve diagnostik işlemler için kullanılabilir.
Oral ve intraosseal kullanımın daha uzun süreli bir anestezi gerektiren
olgularda tercih edilebileceği söylenebilir.
Keywords
References
- 1. Maiti SK, Tiwary R, Vasan P, Dutta A. (2006). Xylazine, diaze-pam and midazolam premedicated ketamine anaesthesia in White Leghorn cockerels for typlectomy. S Afr Vet Ver, 77 (1): 12-18.
- 2. Mans C. (2014) Sedation of pet birds. Journal of Exotic Pet Medicine. 23, 152-157.
- 3. Durrani UF, Khan MA, Ahmad SS. (2008). Comparative efficacy (sedative and anesthetic) of detomidine, ketamine and detomidine-ketamine cocktail in peigeons (Culumbia livia). Pa-kistan Vet J. 28 (3): 115-118.
- 4. Durrani UF, Ashraf M, Khalid A. (2005). Comparative efficacy of detomidine and detomidine cocktail in quails. Pakistan Vet J. 25 (4): 197-199.
- 5. Durrani UF, Ashraf M, Khan MA. (2009). A comparison of the clinical effects associated with xylazine, ketamine and a xylazine-ketamine cocktail in pigeons (Columba livia). Turk J Vet Anim Sci. 33 (5): 413-417.
- 6. Kamiloglu A, Yayla S, Kamiloglu NN, Ozaydin I, Kurt B: Clinical evaluation of intramuscular and intraosseous xylazine-ketamine anesthesia in quails (Coturnix coturnix japonica). Erciyes Üniv Vet Fak Derg. 11(3): 169-174, 2014.
- 7. Yayla S, Kamiloglu N, Kamiloglu A, Ozaydin I: Comparision of intravenous and intraosseous administration of propofol-ketamine combination for anesthesia in quails (Coturnix coturnix japonica). Kocatepe Vet J. 7 (1): 11-16, 2014.
- 8. Yayla S, Kamiloglu NN, Kamiloglu A, Ozaydın I, Ermutlu CS. (2015). Comparison of the effects of intramuscular and in-traosseal administration of detomidine/ ketamine combina-tion for general anaesthesia in quails (Coturnix coturnix japon-ica). Bulg J Agric Sci. 21, 220-224.
- 9. Akgul MB, Sindak N, Gulaydin A, Ozen D. (2017). Clinical evaluation of xylazine-ketamine and medetomidine-ketamine anesthesia in japanese quails (Coturnix coturnix japonica). Erciyes Üniv Vet Fak Derg. 14 (3): 169-176.
- 10. Schaffer DPH, Araujo NNLJ, Raposa ACS, Filho AFM, Vieira JVR, Oria AP. (2017). Sedative effect of intranasal midazolam administration in wild caught blue-fronted amazon (Amozona aestiva) and orange-winged amazon (Amozona amazonica) parrots. J Avian Med Surg. 31(3): 213-218.
- 11. Day TK, Roge CK. (1996). Evaluation of sedation in quail in-duced by use of midazolam and reversed by use of flumazenil. J Am Vet Med Assoc. 209 (5): 969-971.
- 12. Sadegh AB. (2013). Comparison of intranasal administration of xylazine, diazepam, and midazolam in budgerigars (Melopsittacus undalatus): Clinical evaluation. J Zoo Wild Med. 44 (2): 241-244.
- 13. Moghadam AZ, Sadegh AB, Sharifi S, Habibian S. (2009). Comparison of intranasal administration of diazepem midazolam and xylazine in pigeons: Clinical evaluation. IJVST, 1 (1): 19-26.
- 14. Schaffer DPH, Raposa ACS, Liberiou FA, Silva RMM, Araujo NLLJ, Oria AP. (2016). Intranasal administration of midazolam in blue and yellow macaws (Ara araruana): Evaluation of sedative effects. Veterinary Anest Analg. 43, 459-460.
- 15. Kamiloglu A, Atalan G, Kamiloglu NN. (2007). Comparison of intraosseous and intramuscular drug administration for induc-tion of anesthesia in domestic pigeons. Res Vet Sci. 85, 171-175.
- 16. Guzman DSM. (2014). Advances in avian clinical therapeutics. Journal of Exotic Pet Medicine 23, 6-20.
- 17. Valverde AD, Bienzle D, Smith DA, Dyson DH, Valliant AE. (1993). Intraosseus cannulation and drug administration for induction of anesthesia in chickens. Vet Surg. 22, 240-244.
- 18. English MJ, Papenberg R, Farias E, Scott WAC, Hinchey J. (1991). Heat loss in an animal experimental model. J Trauma. 31, 36-38.
Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Surgery |
| Journal Section | Research |
| Authors | |
| Publication Date | December 31, 2018 |
| Acceptance Date | September 20, 2018 |
| Published in Issue | Year 2018 Volume: 11 Issue: 2 |
Cite
DANIŞMA KURULU
Prof. Dr. Abit AKTAŞ, İstanbul Üniversitesi-Cerrahpaşa
Prof. Dr. Yılmaz ARAL, Ankara Üniversitesi
Prof. Dr. Ali ARSLAN, Fırat Üniversitesi, Elazığ
Prof. Dr. M. Sedat BARAN, Dicle Üniversitesi, Diyarbakır
Prof. Dr. Cengiz CEYLAN, Balıkesir Üniversitesi
Prof. Dr. Ahmet ÇAKIR, Ankara Üniversitesi
Prof. Dr. Burhan ÇETİNKAYA, Fırat Üniversitesi, Elazığ
Prof. Dr. Ülker EREN, Adnan Menderes Üniversitesi, Aydın
Prof. Dr. Abdurrahman GÜL, Bingöl Üniversitesi
Prof. Dr. Hakki KARA, Cumhuriyet Üniversitesi, Sivas
Prof. Dr. Narin LİMAN, Erciyes Üniversitesi, Kayseri
Prof. Dr. Abdullah ÖZEN, Fırat Üniversitesi, Elazığ
Prof. Dr. Ayşe SERBEST, Uludağ Üniversitesi, Bursa
Prof. Dr. Kazım ŞAHİN, Fırat Üniversitesi, Elazığ
Prof. Dr. Tekin ŞAHİN, Siirt Üniversitesi
Prof. Dr. Nihat ŞINDAK, Siirt Üniversitesi
Prof. Dr. Muzaffer TAŞ, Namık Kemal Üniversitesi, Tekirdağ
Prof. Dr. Necati TİMURKAN Fırat Üniversitesi, Elazığ
Prof. Dr. Emine ÜNSALDI, Fırat Üniversitesi, Elazığ
Prof. Dr. Murat YILDIRIM, Kırıkkale Üniversitesi
Doç. Dr. M. Osman ATLI, Harran Üniversitesi, Şanlıurfa
Doç. Dr. Bülent ELİTOK, Afyon Kocatepe Üniversitesi
Doç. Dr. Serkan ERDOĞAN, Namık Kemal Üniversitesi, Tekirdağ
Dr. Öğr. Üyesi Zelal KARAKOÇ, Dicle Üniversitesi, Diyarbakır
Dr. Öğr. Üyesi Ersin UYSAL, Dicle Üniversitesi, Diyarbakır
*Not: Yayın ve Danışma Kurulu Üyeleri alfabetik sıraya göre dizilmiştir.